Metal nanoparticles: understanding the mechanisms behind antibacterial activity

As the field of nanomedicine emerges, there is a lag in research surrounding the topic of nanoparticle (NP) toxicity, particularly concerned with mechanisms of action. The continuous emergence of bacterial resistance has challenged the research community to develop novel antibiotic agents. Metal NPs...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of nanobiotechnology Jg. 15; H. 1; S. 65 - 20
Hauptverfasser: Slavin, Yael N., Asnis, Jason, Häfeli, Urs O., Bach, Horacio
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 03.10.2017
BioMed Central Ltd
Springer Nature B.V
BMC
Schlagworte:
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial activity
Antibacterial agents
Antibiotics
Antimicrobial agents
Bacteria
Bacteria - cytology
Bacteria - drug effects
Bacteria - genetics
Bacteria - metabolism
Bacterial Infections - drug therapy
Bacterial Infections - microbiology
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Biochemistry
Biotechnology
Chemistry
Chemistry and Materials Science
Damage
Dosage and administration
Drug resistance in microorganisms
E coli
Escherichia coli
Gene expression
Gene Expression Regulation, Bacterial - drug effects
Gene regulation
Gram-negative bacteria
Gram-positive bacteria
Health aspects
Humans
Mechanism of defense
Metal Nanoparticles - chemistry
Metals
Molecular Medicine
Nanoparticles
Nanotechnology
Proteins
Proteomics
Reactive oxygen species
Reactive Oxygen Species - metabolism
Review
ROS
Staphylococcus aureus
Studies
Toxicity
Transcriptome - drug effects
Transcriptomics
Transmission electron microscopy
Nanoparticles
Transcriptomics
Metals
Gene regulation
ROS
Proteomics
Bacteria
Mechanism of defense
Antibacterial resistance
ISSN:1477-3155, 1477-3155
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:As the field of nanomedicine emerges, there is a lag in research surrounding the topic of nanoparticle (NP) toxicity, particularly concerned with mechanisms of action. The continuous emergence of bacterial resistance has challenged the research community to develop novel antibiotic agents. Metal NPs are among the most promising of these because show strong antibacterial activity. This review summarizes and discusses proposed mechanisms of antibacterial action of different metal NPs. These mechanisms of bacterial killing include the production of reactive oxygen species, cation release, biomolecule damages, ATP depletion, and membrane interaction. Finally, a comprehensive analysis of the effects of NPs on the regulation of genes and proteins (transcriptomic and proteomic) profiles is discussed.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:1477-3155
1477-3155
DOI:10.1186/s12951-017-0308-z