Engineering CAR-T cells

Chimeric antigen receptor redirected T cells (CAR-T cells) have achieved inspiring outcomes in patients with B cell malignancies, and are now being investigated in other hematologic malignancies and solid tumors. CAR-T cells are generated by the T cells from patients’ or donors’ blood. After the T c...

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Vydané v:Biomarker research Ročník 5; číslo 1; s. 22 - 6
Hlavní autori: Zhang, Cheng, Liu, Jun, Zhong, Jiang F., Zhang, Xi
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London BioMed Central 24.06.2017
BioMed Central Ltd
Springer Nature B.V
BMC
Predmet:
Antigens
Apoptosis
Biomedical and Life Sciences
Biomedicine
Cancer Research
CAR-T cells
Cell receptors
Chimeric antigen receptor redirected T cells
Chimeric antigen receptors
Cytokines
Evolution
Genetic aspects
Genetic engineering
Genetic research
Health aspects
Kinases
Lymphocytes
Lymphocytes B
Lymphocytes T
Peptides
Production
Proteins
Review
Signal transduction
Solid tumors
Structure
T cell receptors
T cells
Tumors
Viral vector
Evolution
Viral vector
Structure
Chimeric antigen receptor redirected T cells
CAR-T cells
Production
ISSN:2050-7771, 2050-7771
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Popis
Shrnutí:Chimeric antigen receptor redirected T cells (CAR-T cells) have achieved inspiring outcomes in patients with B cell malignancies, and are now being investigated in other hematologic malignancies and solid tumors. CAR-T cells are generated by the T cells from patients’ or donors’ blood. After the T cells are expanded and genetically modified, they are reinfused into the patients. However, many challenges still need to be resolved in order for this technology to gain widespread adoption. In this review, we first discuss the structure and evolution of chimeric antigen receptors. We then report on the tools used for production of CAR-T cells. Finally, we address the challenges posed by CAR-T cells.
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ISSN:2050-7771
2050-7771
DOI:10.1186/s40364-017-0102-y