Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management

Primary sclerosing cholangitis (PSC), first described in the mid-1850s, is a complex liver disease that is heterogeneous in its presentation. PSC is characterized by chronic cholestasis associated with chronic inflammation of the biliary epithelium, resulting in multifocal bile duct strictures that...

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Vydáno v:	Gastroenterology (New York, N.Y. 1943) Ročník 145; číslo 3; s. 521
Hlavní autoři:	Eaton, John E, Talwalkar, Jayant A, Lazaridis, Konstantinos N, Gores, Gregory J, Lindor, Keith D
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.09.2013
Témata:	Bile Duct Neoplasms - diagnosis Bile Duct Neoplasms - etiology Bile Duct Neoplasms - therapy Bile Ducts, Intrahepatic Cholagogues and Choleretics - therapeutic use Cholangiocarcinoma - diagnosis Cholangiocarcinoma - etiology Cholangiocarcinoma - therapy Cholangiopancreatography, Endoscopic Retrograde Cholangitis, Sclerosing - diagnosis Cholangitis, Sclerosing - etiology Cholangitis, Sclerosing - therapy Colonic Neoplasms - diagnosis Colonic Neoplasms - etiology Colonic Neoplasms - therapy Combined Modality Therapy Diagnosis, Differential Gallbladder Neoplasms - diagnosis Gallbladder Neoplasms - etiology Gallbladder Neoplasms - therapy Genetic Predisposition to Disease Humans Immunity, Innate Immunosuppressive Agents Intestines - microbiology Liver Transplantation Metagenome Ursodeoxycholic Acid - therapeutic use magnetic resonance LT UDCA TNF UC endoscopic retrograde cholangiopancreatography Autoimmune Disease gallbladder neoplasia Th MDR ulcerative colitis Inflammatory Bowel Disease carbohydrate antigen Toll-like receptor hepatocellular carcinoma AIH PSC IL MR janus kinase mucosal addressin cellular adhesion molecule 1 AIP LGD HCC autoimmune pancreatitis IAC fluorescence in situ hybridization VAP-1 CFTR CRN Ig LPC primary sclerosing cholangitis FXR Cholestatic Liver Disease immunoglobulin G4–associated cholangitis IBD low-grade dysplasia GBN T-helper autoimmune hepatitis ursodeoxycholic acid lymphoplasmacytic TLR interleukin liver transplant CA Cholangiocarcinoma CCA MAdCAM-1 colorectal neoplasia immunoglobulin farnesoid X receptor vascular adhesion protein 1 multidrug resistance protein tumor necrosis factor JAK MRCP FISH cystic fibrosis transmembrane conductance regulator ERCP magnetic resonance cholangiopancreatography
ISSN:	1528-0012, 1528-0012
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