Modeling protein folding in vivo

A half century of studying protein folding in vitro and modeling it in silico has not provided us with a reliable computational method to predict the native conformations of proteins de novo, let alone identify the intermediates on their folding pathways. In this Opinion article, we suggest that the...

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Vydáno v:	Biology direct Ročník 13; číslo 1; s. 13 - 14
Hlavní autoři:	Sorokina, Irina, Mushegian, Arcady
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 06.07.2018 BioMed Central Ltd Springer Nature B.V BMC
Témata:	Animals Biomedical and Life Sciences Chaperone Chaperones Chemical treatment Co-translational protein folding Computation Computational biology Computer applications Data processing Denaturation Energy Entropy Experiments Folding Genetic engineering Genetic research Heat treatment Humans Hypotheses Intermediates Life Sciences Molecular chains Molecular machines Opinion Organic chemistry Peptidyl Transferases - metabolism Physiology Post-translation Protein Binding Protein Biosynthesis Protein Conformation Protein Folding Protein folding in vivo Protein folding machine Proteins Proteins - chemistry Proteins - metabolism Reverse engineering Ribosome Ribosomes - metabolism Translation Trigger factor Metastable protein Protein folding machine Ribosome Chaperone Trigger factor Fast protein folding Co-translational protein folding Motions at the peptidyl transferase center Peptide rotation Protein folding in vivo
ISSN:	1745-6150, 1745-6150
On-line přístup:	Získat plný text
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