Current biomarkers of canine mammary tumors

Mammary tumors are the second most common neoplasia in dogs. Due to the high similarity of canine mammary tumors (CMT) to human breast cancers (HBC), human biomarkers of HBC are also detectable in cases of CMT. The evaluation of biomarkers enables clinical diagnoses, treatment options and prognosis...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Acta veterinaria scandinavica Ročník 60; číslo 1; s. 66
Hlavní autoři:	Kaszak, Ilona, Ruszczak, Anna, Kanafa, Szymon, Kacprzak, Kamil, Król, Magdalena, Jurka, Piotr
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 29.10.2018 BioMed Central Ltd Nature Publishing Group BMC
Témata:	Analysis Animal Anatomy Animals Antigens Biomarkers Biomarkers - blood Bitch bitches blood serum BRCA1 protein BRCA2 protein Breast cancer breast neoplasms cadherins Cancer Cancer therapies Canine mammary gland Canine mammary tumors Carcinoembryonic antigen Chemotherapy Cyclooxygenase-1 Cyclooxygenase-2 Diagnosis Dog Dog Diseases - blood Dogs E-cadherin Epidermal growth factor ErbB-2 protein erbB-2 receptor estrogen receptors Female genes Growth factors Health aspects Histology Human breast cancer humans Identification Life expectancy Lymphatic system mammary neoplasms (animal) Mammary Neoplasms, Animal - blood Medical prognosis Medicine Medicine & Public Health Metastasis microRNA MicroRNAs miRNA Morphology Mutation neoplasm cells p53 Protein Progesterone progesterone receptors Prognosis proliferating cell nuclear antigen prostaglandin synthase Radiation therapy Review Stem cells Tumor cells tumor suppressor proteins Tumors Vascular endothelial growth factor vascular endothelial growth factor receptors vascular endothelial growth factors Veterinary Medicine/Veterinary Science Bitch Biomarkers Human breast cancer Veterinary oncology Canine mammary gland Neoplasia Dog Canine mammary tumors
ISSN:	1751-0147, 0044-605X, 1751-0147
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	Mammary tumors are the second most common neoplasia in dogs. Due to the high similarity of canine mammary tumors (CMT) to human breast cancers (HBC), human biomarkers of HBC are also detectable in cases of CMT. The evaluation of biomarkers enables clinical diagnoses, treatment options and prognosis for bitches suffering from this disease. The aim of this article is to give a short summary of the biomarkers of CMT based on current literature. Very promising biomarkers are miRNAs, cancer stem cells, and circulating tumor cells, as well as mutations of the breast cancer 1 gene (BRCA1) and breast cancer 2 gene (BRCA2). Until now, the most studied and reliable biomarkers of CMT have remained antigen Ki-67 (Ki-67), endothelial growth factor receptor, human epidermal growth factor receptor 2 (HER-2), estrogen receptor, progesterone receptor and cyclooxygenase 1 (COX-2), which can be detected in both serum and tissue samples using different molecular methods. However, carcinoembryonic antigen and cancer antigen 15-3 (CA 15-3), while poorly studied, seem to be good biomarkers, especially for the early detection and prognosis of CMT. We will also mention the following: proliferative cell nuclear antigen, tumor protein p53 (p53), E-cadherin, vascular endothelial growth factor, microRNAs, cancer stem cells and circulating tumor cells, which can also be useful biomarkers. Although many studies have been conducted so far, the estimation of biomarkers in cases of CMT is still not a common practice, and more detailed research should be done.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1751-0147 0044-605X 1751-0147
DOI:	10.1186/s13028-018-0417-1