Functional circuit architecture underlying parental behaviour

Parenting is essential for the survival and wellbeing of mammalian offspring. However, we lack a circuit-level understanding of how distinct components of this behaviour are coordinated. Here we investigate how galanin-expressing neurons in the medial preoptic area (MPOA Gal ) of the hypothalamus co...

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Vydané v:	Nature (London) Ročník 556; číslo 7701; s. 326 - 331
Hlavní autori:	Kohl, Johannes, Babayan, Benedicte M., Rubinstein, Nimrod D., Autry, Anita E., Marin-Rodriguez, Brenda, Kapoor, Vikrant, Miyamishi, Kazunari, Zweifel, Larry S., Luo, Liqun, Uchida, Naoshige, Dulac, Catherine
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 01.04.2018 Nature Publishing Group
Predmet:	13/1 13/51 14/32 14/35 14/63 38 38/44 42 59 631/378/3919 631/378/3920 64 64/60 9/10 Animal behavior Animals Architecture Brain Circuits Dopamine Female Females Functional morphology Galanin Galanin - metabolism Hormones - metabolism Humanities and Social Sciences Hypothalamus Logic Male Maternal Behavior - physiology Maternal Behavior - psychology Mice Mothers Motivation Motor task performance Mouse devices multidisciplinary Neural circuitry Neural Pathways Neurons Neurons - metabolism Neuropeptides Neurosciences Observations Offspring Optogenetics Parental behavior Parenting Paternal Behavior - physiology Paternal Behavior - psychology Physiological aspects Pools Preoptic area Preoptic Area - cytology Preoptic Area - physiology Psychological aspects Rabies Reproduction - physiology Rodents Science Science (multidisciplinary) Sex Characteristics Social Behavior Social factors Spinal cord
ISSN:	0028-0836, 1476-4687, 1476-4687
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Shrnutí:	Parenting is essential for the survival and wellbeing of mammalian offspring. However, we lack a circuit-level understanding of how distinct components of this behaviour are coordinated. Here we investigate how galanin-expressing neurons in the medial preoptic area (MPOA Gal ) of the hypothalamus coordinate motor, motivational, hormonal and social aspects of parenting in mice. These neurons integrate inputs from a large number of brain areas and the activation of these inputs depends on the animal’s sex and reproductive state. Subsets of MPOA Gal neurons form discrete pools that are defined by their projection sites. While the MPOA Gal population is active during all episodes of parental behaviour, individual pools are tuned to characteristic aspects of parenting. Optogenetic manipulation of MPOA Gal projections mirrors this specificity, affecting discrete parenting components. This functional organization, reminiscent of the control of motor sequences by pools of spinal cord neurons, provides a new model for how discrete elements of a social behaviour are generated at the circuit level. Galanin-expressing neurons in the medial preoptic area coordinate different aspects of motor, motivational, hormonal and social behaviour associated with parenting by projecting to different brain regions depending on the type of behaviour and sex and reproductive state of mice.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0028-0836 1476-4687 1476-4687
DOI:	10.1038/s41586-018-0027-0