K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

Pediatric glioblastomas (GBM) including diffuse intrinsic pontine gliomas (DIPG) are devastating brain tumors with no effective therapy. Here, we investigated clinical and biological impacts of histone H3.3 mutations. Forty-two DIPGs were tested for H3.3 mutations. Wild-type versus mutated (K27M-H3....

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Bibliographic Details
Published in:	Acta neuropathologica Vol. 124; no. 3; pp. 439 - 447
Main Authors:	Khuong-Quang, Dong-Anh, Buczkowicz, Pawel, Rakopoulos, Patricia, Liu, Xiao-Yang, Fontebasso, Adam M., Bouffet, Eric, Bartels, Ute, Albrecht, Steffen, Schwartzentruber, Jeremy, Letourneau, Louis, Bourgey, Mathieu, Bourque, Guillaume, Montpetit, Alexandre, Bourret, Genevieve, Lepage, Pierre, Fleming, Adam, Lichter, Peter, Kool, Marcel, von Deimling, Andreas, Sturm, Dominik, Korshunov, Andrey, Faury, Damien, Jones, David T., Majewski, Jacek, Pfister, Stefan M., Jabado, Nada, Hawkins, Cynthia
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer-Verlag 01.09.2012 Springer Springer Nature B.V
Subjects:	Adolescent Algorithms Biopsy Brain cancer Brain research Brain stem Brain Stem Neoplasms - genetics Brain Stem Neoplasms - mortality Brain Stem Neoplasms - pathology Brain tumors Cancer research Cancer therapies Child Child, Preschool Children Clinical trials Comparative analysis copy number Cortex Decision making Female Gene Expression Profiling Genetic aspects Glioblastoma Glioma Glioma - genetics Glioma - mortality Glioma - pathology Gliomas Histones Histones - genetics Hospitals Humans Infant Kinases Male Medical research Medicine Medicine & Public Health Mutation Myc protein Neurosciences Original Paper p53 protein Pathology Pediatrics Platelet-derived growth factor Pons - pathology Prognosis Survival Survival Rate Tumor proteins Tumors Canada Montreal Quebec Canada Germany H3.3 DIPG Targeted therapy TP53 Survival ATRX
ISSN:	0001-6322, 1432-0533, 1432-0533
Online Access:	Get full text
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