Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

John Perry and colleagues report the results of a large genome-wide association study meta-analysis to identify variants influencing age at natural menopause. They identify 54 independent signals and find enrichment near genes involved in delayed puberty and DNA damage response. Menopause timing has...

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Published in:	Nature genetics Vol. 47; no. 11; pp. 1294 - 1303
Main Authors:	Thompson, Deborah J, Pervjakova, Natalia, Chasman, Daniel I, Esko, Tõnu, Elks, Cathy E, He, Chunyan, Altmaier, Elisabeth, Huffman, Jennifer E, Keller, Margaux F, McArdle, Patrick F, Nutile, Teresa, Porcu, Eleonora, Corre, Tanguy, Smith, Albert V, Antoniou, Antonis C, Barbieri, Caterina, Bielinski, Suzette J, Blomqvist, Carl, Boerwinkle, Eric, Bogdanova, Natalia V, Bojesen, Stig E, Borresen-Dale, Anne-Lise, Chapman, J Ross, Couch, Fergus J, Coviello, Andrea D, Cox, Angela, Czene, Kamila, Demerath, Ellen W, Devilee, Peter, Dörk, Thilo, dos-Santos-Silva, Isabel, Dunning, Alison M, Eicher, John D, Fasching, Peter A, Faul, Jessica D, Garcia, Melissa E, Girotto, Giorgia G, Goldberg, Mark S, Gudbjartsson, Daniel F, Haiman, Christopher A, Homuth, Georg, Hu, Frank B, Hunter, David J, Jakubowska, Anna, Kosma, Veli-Matti, Kriebel, Jennifer, Kristensen, Vessela, Langenberg, Claudia, Liu, Yongmei, Luan, Jian'an, Manz, Judith, Masciullo, Corrado, Milani, Lili, Milne, Roger L, Müller-Nurasyid, Martina, Neale, Benjamin M, Neven, Patrick, Newman, Anne B, Nordestgaard, Børge G, Padmanabhan, Sandosh, Peters, Ulrike, Peto, Julian, Pirie, Ailith, Pistis, Giorgio, Porteous, David, Psaty, Bruce M, Pylkäs, Katri, Radice, Paolo, Rivadeneira, Fernando, Rudan, Igor, Sawyer, Elinor J, Schlessinger, David, Schmidt, Marjanka K, Schmidt, Frank, Seynaeve, Caroline M, Simard, Jacques, Southey, Melissa C, Stöckl, Doris, Strauch, Konstantin, Toland, Amanda E, Tomlinson, Ian, Tryggvadottir, Laufey, Turner, Stephen T, Willemsen, Gonneke, Wright, Alan F, Zygmunt, Marek, Bergmann, Sven, Boomsma, Dorret I, Montgomery, Grant W, van Duijn, Cornelia M, Alizadeh, Behrooz Z, Crisponi, Laura, Easton, Douglas F, Harris, Tamara B, Kraft, Peter, McKnight, Barbara, Rotter, Jerome I, Ulivi, Sheila, Wareham, Nicholas J, Yerges-Armstrong, Laura M
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.11.2015 Nature Publishing Group
Subjects:	45 45/43 631/208/205/2138 692/699/67/1347 Adult Age Factors Aging - genetics Agriculture Animal Genetics and Genomics Biomedicine BRCA1 Protein - genetics Breast cancer Breast Neoplasms - genetics Cancer Research Cellular signal transduction Consortia Deoxyribonucleic acid Development and progression Disease susceptibility DNA DNA Repair Female Gene Function Gene Regulatory Networks - genetics Genealogy Genetic aspects Genetic Predisposition to Disease - genetics Genetic Variation Genome-Wide Association Study - methods Genomes Genomics - methods Genotype Health aspects Health risks Human Genetics Humans Hypothalamus - metabolism Identification and classification Infertility Menopause Menopause - genetics Meta-analysis Middle Aged Models, Genetic Phenotype Reproduction - genetics Signal Transduction - genetics Studies Womens health
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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