Identification of atrial fibrillation associated genes and functional non-coding variants

Disease-associated genetic variants that lie in non-coding regions found by genome-wide association studies are thought to alter the functionality of transcription regulatory elements and target gene expression. To uncover causal genetic variants, variant regulatory elements and their target genes,...

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Veröffentlicht in:	Nature Communications Jg. 10; H. 1; S. 4755 - 14
Hauptverfasser:	van Ouwerkerk, Antoinette F., Bosada, Fernanda M., van Duijvenboden, Karel, Hill, Matthew C., Montefiori, Lindsey E., Scholman, Koen T., Liu, Jia, de Vries, Antoine A. F., Boukens, Bastiaan J., Ellinor, Patrick T., Goumans, Marie José T. H., Efimov, Igor R., Nobrega, Marcelo A., Barnett, Phil, Martin, James F., Christoffels, Vincent M.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Springer Science and Business Media LLC 18.10.2019 Nature Publishing Group UK Nature Publishing Group Nature Portfolio
Schlagworte:	38 38/91 631/208/200 631/208/4041 631/337/100 631/337/572/2102 64 64/60 692/4019/592/75 Animals Atrial Fibrillation Atrial Fibrillation - genetics Cardiac arrhythmia Cardiomyocytes Cell Line Chromatin Chromatin - genetics Conformation Connexin 43 Epigenomics Epigenomics - methods Fibrillation Gap junctions Gene expression Gene Expression Profiling Gene Expression Profiling - methods Gene regulation Genes Genetic diversity Genetic Predisposition to Disease Genetic Predisposition to Disease - genetics Genetic variance Genetic Variation Genome-wide association studies Genome-Wide Association Study Genome-Wide Association Study - methods Genomes Heart Atria Heart Atria - cytology Heart Atria - metabolism Homology Humanities and Social Sciences Humans Mice multidisciplinary Myocytes, Cardiac Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Polymorphism, Single Nucleotide Q Regulatory sequences Regulatory Sequences, Nucleic Acid Regulatory Sequences, Nucleic Acid - genetics Science Science (multidisciplinary) Transcription
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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