Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo

Joon-Mo Yang and colleagues have developed a new endoscopic technique for the in vivo imaging of internal organs, combining endoscopic ultrasound and photoacoustic endoscopy in a single instrument. In addition to improved resolution, imaging depth, multimodal contrast, and distal-end scanning, the n...

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Veröffentlicht in:Nature medicine Jg. 18; H. 8; S. 1297 - 1302
Hauptverfasser: Yang, Joon-Mo, Favazza, Christopher, Chen, Ruimin, Yao, Junjie, Cai, Xin, Maslov, Konstantin, Zhou, Qifa, Shung, K Kirk, Wang, Lihong V
Format: Journal Article
Sprache:Englisch
Veröffentlicht: New York Nature Publishing Group US 01.08.2012
Nature Publishing Group
Schlagworte:
692/700/1421/164
Acoustics
Anatomy, Cross-Sectional
Animals
Biomedical and Life Sciences
Biomedicine
Blood Vessels - chemistry
Blood Vessels - diagnostic imaging
Cancer Research
Coloring Agents
Digestive System - chemistry
Digestive System - diagnostic imaging
Endoscopic surgery
Endoscopic ultrasonography
Endosonography - instrumentation
Endosonography - methods
Equipment Design
Evans Blue
Gastrointestinal system
Hemoglobins - analysis
Imaging, Three-Dimensional
Infectious Diseases
Lymphatic System - diagnostic imaging
Medical imaging
Metabolic Diseases
Methods
Molecular Medicine
Neurosciences
Organ Size
Organs
Oxygen - analysis
Photoacoustic spectroscopy
Photoacoustic Techniques
Rabbits
Rats
Rats, Sprague-Dawley
Respiratory System - chemistry
Respiratory System - diagnostic imaging
Surgical techniques
technical-report
Tomography - methods
Ultrasonic imaging
United States
ISSN:1078-8956, 1546-170X, 1546-170X
Online-Zugang:Volltext
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Zusammenfassung:Joon-Mo Yang and colleagues have developed a new endoscopic technique for the in vivo imaging of internal organs, combining endoscopic ultrasound and photoacoustic endoscopy in a single instrument. In addition to improved resolution, imaging depth, multimodal contrast, and distal-end scanning, the new hybrid imaging modality can also provide functional information such as hemoglobin concentration and blood oxygenation. Feasibility is shown in vivo by simultaneous photoacoustic endoscopy and endoscopic ultrasound imaging of the upper and lower gastrointestinal tracts of rats and rabbits. At present, clinicians routinely apply ultrasound endoscopy in a variety of interventional procedures that provide treatment solutions for diseased organs. Ultrasound endoscopy not only produces high-resolution images, but also is safe for clinical use and broadly applicable. However, for soft tissue imaging, its mechanical wave–based image contrast fundamentally limits its ability to provide physiologically specific functional information. By contrast, photoacoustic endoscopy possesses a unique combination of functional optical contrast and high spatial resolution at clinically relevant depths, ideal for imaging soft tissues. With these attributes, photoacoustic endoscopy can overcome the current limitations of ultrasound endoscopy. Moreover, the benefits of photoacoustic imaging do not come at the expense of existing ultrasound functions; photoacoustic endoscopy systems are inherently compatible with ultrasound imaging, thereby enabling multimodality imaging with complementary contrast. Here we present simultaneous photoacoustic and ultrasonic dual-mode endoscopy and show its ability to image internal organs in vivo , thus illustrating its potential clinical application.
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ISSN:1078-8956
1546-170X
1546-170X
DOI:10.1038/nm.2823