Exploring the pre-immune landscape of antigen-specific T cells

Background Adaptive immune responses to newly encountered pathogens depend on the mobilization of antigen-specific clonotypes from a vastly diverse pool of naive T cells. Using recent advances in immune repertoire sequencing technologies, models of the immune receptor rearrangement process, and a da...

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Bibliographic Details
Published in:	Genome medicine Vol. 10; no. 1; pp. 68 - 14
Main Authors:	Pogorelyy, Mikhail V., Fedorova, Alla D., McLaren, James E., Ladell, Kristin, Bagaev, Dmitri V., Eliseev, Alexey V., Mikelov, Artem I., Koneva, Anna E., Zvyagin, Ivan V., Price, David A., Chudakov, Dmitry M., Shugay, Mikhail
Format:	Journal Article
Language:	English
Published:	London BioMed Central 25.08.2018 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Adaptive immunity Ankylosing spondylitis Antigen Antigens Bioinformatics Biomedical and Life Sciences Biomedicine Cancer Research Care and treatment Computer applications Cord blood Cytomegalovirus Epitopes Epitopes - immunology Estimates Genetic aspects Genomics of Infection and Immunity Histocompatibility antigen HLA Histocompatibility Antigens Class I - immunology Human Genetics Humans Immune repertoire Immune system Immunogenicity Lymphocytes Lymphocytes T Medicine/Public Health Metabolomics Models, Statistical Multiculturalism & pluralism Pathogens Peptides - immunology Physicochemical properties Receptors, Antigen, T-Cell - immunology Systems Biology T cell receptor T cell receptors T cells T-Lymphocytes - immunology Umbilical cord Antigen T cell receptor Immunogenicity Immune repertoire
ISSN:	1756-994X, 1756-994X
Online Access:	Get full text
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