Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

It is believed that lipid accumulation in the liver, or fatty liver disease, contributes to insulin resistance in this organ and, thus, poorly controlled gluconeogenesis and hyperglycemia during type 2 diabetes. Mitch Lazar and colleagues now show that deletion of the chromatin modifier Hdac3 in mic...

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Bibliographic Details
Published in:	Nature medicine Vol. 18; no. 6; pp. 934 - 942
Main Authors:	Sun, Zheng, Miller, Russell A, Patel, Rajesh T, Chen, Jie, Dhir, Ravindra, Wang, Hong, Zhang, Dongyan, Graham, Mark J, Unterman, Terry G, Shulman, Gerald I, Sztalryd, Carole, Bennett, Michael J, Ahima, Rexford S, Birnbaum, Morris J, Lazar, Mitchell A
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.06.2012 Nature Publishing Group
Subjects:	692/698/2741/288 692/699/2743/137 692/699/2743/393 Analysis Animals Biomedical and Life Sciences Biomedicine Biosynthesis Body weight Cancer Research Circadian rhythms Depletion Diet, High-Fat Fatty Liver - etiology Gluconeogenesis Glucose - metabolism Histone Deacetylases - physiology Infectious Diseases Insulin - blood Insulin Resistance Lipids Lipids - biosynthesis Liver Liver - enzymology Liver diseases Male Metabolic Diseases Mice Mice, Inbred C57BL Molecular Medicine Neurosciences Non-alcoholic Fatty Liver Disease Obesity
ISSN:	1078-8956, 1546-170X, 1546-170X
Online Access:	Get full text
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