Multifunctional coatings to simultaneously promote osseointegration and prevent infection of orthopaedic implants
The two leading causes of failure for joint arthroplasty prostheses are aseptic loosening and periprosthetic joint infection. With the number of primary and revision joint replacement surgeries on the rise, strategies to mitigate these failure modes have become increasingly important. Much of the re...
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| Veröffentlicht in: | Biomaterials Jg. 84; S. 301 - 314 |
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| Hauptverfasser: | , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Netherlands
Elsevier Ltd
01.04.2016
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| Schlagworte: | |
| ISSN: | 0142-9612, 1878-5905, 1878-5905 |
| Online-Zugang: | Volltext |
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| Abstract | The two leading causes of failure for joint arthroplasty prostheses are aseptic loosening and periprosthetic joint infection. With the number of primary and revision joint replacement surgeries on the rise, strategies to mitigate these failure modes have become increasingly important. Much of the recent work in this field has focused on the design of coatings either to prevent infection while ignoring bone mineralization or vice versa, to promote osseointegration while ignoring microbial susceptibility. However, both coating functions are required to achieve long-term success of the implant; therefore, these two modalities must be evaluated in parallel during the development of new orthopaedic coating strategies. In this review, we discuss recent progress and future directions for the design of multifunctional orthopaedic coatings that can inhibit microbial cells while still promoting osseointegration. |
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| AbstractList | Abstract The two leading causes of failure for joint arthroplasty prostheses are aseptic loosening and periprosthetic joint infection. With the number of primary and revision joint replacement surgeries on the rise, strategies to mitigate these failure modes have become increasingly important. Much of the recent work in this field has focused on the design of coatings either to prevent infection while ignoring bone mineralization or vice versa, to promote osseointegration while ignoring microbial susceptibility. However, both coating functions are required to achieve long-term success of the implant; therefore, these two modalities must be evaluated in parallel during the development of new orthopaedic coating strategies. In this review, we discuss recent progress and future directions for the design of multifunctional orthopaedic coatings that can inhibit microbial cells while still promoting osseointegration. The two leading causes of failure for joint arthroplasty prostheses are aseptic loosening and periprosthetic joint infection. With the number of primary and revision joint replacement surgeries on the rise, strategies to mitigate these failure modes have become increasingly important. Much of the recent work in this field has focused on the design of coatings either to prevent infection while ignoring bone mineralization or vice versa, to promote osseointegration while ignoring microbial susceptibility. However, both coating functions are required to achieve long-term success of the implant; therefore, these two modalities must be evaluated in parallel during the development of new orthopaedic coating strategies. In this review, we discuss recent progress and future directions for the design of multifunctional orthopaedic coatings that can inhibit microbial cells while still promoting osseointegration. The two leading causes of failure for joint arthroplasty prostheses are aseptic loosening and periprosthetic joint infection. With the number of primary and revision joint replacement surgeries on the rise, strategies to mitigate these failure modes have become increasingly important. Much of the recent work in this field has focused on the design of coatings either to prevent infection while ignoring bone mineralization or vice versa, to promote osseointegration while ignoring microbial susceptibility. However, both coating functions are required to achieve long-term success of the implant; therefore, these two modalities must be evaluated in parallel during the development of new orthopaedic coating strategies. In this review, we discuss recent progress and future directions for the design of multifunctional orthopaedic coatings that can inhibit microbial cells while still promoting osseointegration.The two leading causes of failure for joint arthroplasty prostheses are aseptic loosening and periprosthetic joint infection. With the number of primary and revision joint replacement surgeries on the rise, strategies to mitigate these failure modes have become increasingly important. Much of the recent work in this field has focused on the design of coatings either to prevent infection while ignoring bone mineralization or vice versa, to promote osseointegration while ignoring microbial susceptibility. However, both coating functions are required to achieve long-term success of the implant; therefore, these two modalities must be evaluated in parallel during the development of new orthopaedic coating strategies. In this review, we discuss recent progress and future directions for the design of multifunctional orthopaedic coatings that can inhibit microbial cells while still promoting osseointegration. |
| Author | Holodniy, Mark Raphel, Jordan Heilshorn, Sarah C. Goodman, Stuart B. |
| AuthorAffiliation | 3 Department of Orthopaedic Surgery, Stanford University, Stanford, CA 1 Department of Materials Science and Engineering, Stanford University, Stanford, CA 2 Division of Infectious Diseases, Palo Alto Veterans Affairs Health Care System, Palo Alto, CA |
| AuthorAffiliation_xml | – name: 3 Department of Orthopaedic Surgery, Stanford University, Stanford, CA – name: 2 Division of Infectious Diseases, Palo Alto Veterans Affairs Health Care System, Palo Alto, CA – name: 1 Department of Materials Science and Engineering, Stanford University, Stanford, CA |
| Author_xml | – sequence: 1 givenname: Jordan surname: Raphel fullname: Raphel, Jordan organization: Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA – sequence: 2 givenname: Mark surname: Holodniy fullname: Holodniy, Mark organization: Division of Infectious Diseases & Geographic Medicine, Stanford University, Stanford, CA, USA – sequence: 3 givenname: Stuart B. surname: Goodman fullname: Goodman, Stuart B. organization: Department of Orthopaedic Surgery and Bioengineering, Stanford University, Stanford, CA, USA – sequence: 4 givenname: Sarah C. surname: Heilshorn fullname: Heilshorn, Sarah C. email: heilshorn@stanford.edu organization: Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26851394$$D View this record in MEDLINE/PubMed |
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| Snippet | The two leading causes of failure for joint arthroplasty prostheses are aseptic loosening and periprosthetic joint infection. With the number of primary and... Abstract The two leading causes of failure for joint arthroplasty prostheses are aseptic loosening and periprosthetic joint infection. With the number of... |
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| SubjectTerms | Advanced Basic Science Animals Antimicrobial treatments Bacteria - growth & development bone mineralization Coated Materials, Biocompatible - pharmacology coatings Dentistry Functional coatings Humans Joint Prosthesis - adverse effects Orthopaedic implants orthopedics Osseointegration Osseointegration - drug effects prostheses Prosthesis Failure Prosthesis-Related Infections - microbiology Prosthesis-Related Infections - prevention & control surgery |
| Title | Multifunctional coatings to simultaneously promote osseointegration and prevent infection of orthopaedic implants |
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