Multifunctional coatings to simultaneously promote osseointegration and prevent infection of orthopaedic implants

The two leading causes of failure for joint arthroplasty prostheses are aseptic loosening and periprosthetic joint infection. With the number of primary and revision joint replacement surgeries on the rise, strategies to mitigate these failure modes have become increasingly important. Much of the re...

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Bibliographic Details
Published in:Biomaterials Vol. 84; pp. 301 - 314
Main Authors: Raphel, Jordan, Holodniy, Mark, Goodman, Stuart B., Heilshorn, Sarah C.
Format: Journal Article
Language:English
Published: Netherlands Elsevier Ltd 01.04.2016
Subjects:
Advanced Basic Science
Animals
Antimicrobial treatments
Bacteria - growth & development
bone mineralization
Coated Materials, Biocompatible - pharmacology
coatings
Dentistry
Functional coatings
Humans
Joint Prosthesis - adverse effects
Orthopaedic implants
orthopedics
Osseointegration
Osseointegration - drug effects
prostheses
Prosthesis Failure
Prosthesis-Related Infections - microbiology
Prosthesis-Related Infections - prevention & control
surgery
Functional coatings
Osseointegration
Antimicrobial treatments
Orthopaedic implants
ISSN:0142-9612, 1878-5905, 1878-5905
Online Access:Get full text
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Summary:The two leading causes of failure for joint arthroplasty prostheses are aseptic loosening and periprosthetic joint infection. With the number of primary and revision joint replacement surgeries on the rise, strategies to mitigate these failure modes have become increasingly important. Much of the recent work in this field has focused on the design of coatings either to prevent infection while ignoring bone mineralization or vice versa, to promote osseointegration while ignoring microbial susceptibility. However, both coating functions are required to achieve long-term success of the implant; therefore, these two modalities must be evaluated in parallel during the development of new orthopaedic coating strategies. In this review, we discuss recent progress and future directions for the design of multifunctional orthopaedic coatings that can inhibit microbial cells while still promoting osseointegration.
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ISSN:0142-9612
1878-5905
1878-5905
DOI:10.1016/j.biomaterials.2016.01.016