Grade III meningioma with gastro-intestinal tract and brain metastases: case report and review of the literature

Background Meningioma is the most common adult primary intracranial tumor. Malignant meningioma is a rare variant of meningioma. The prognosis for the patients with these tumors is poor, due to the tumor’s capacity for relapse and to develop distant metastases. These tumors can present the same evol...

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Bibliographic Details
Published in:World journal of surgical oncology Vol. 17; no. 1; pp. 70 - 8
Main Authors: Bender, Laura, Lhermitte, Benoit, Carinato, Hélène, Baloglu, Seyyid, Helali, Mehdi, Cebula, Hélène, Antoni, Delphine, Noel, Georges
Format: Journal Article
Language:English
Published: London BioMed Central 16.04.2019
BioMed Central Ltd
BMC
Subjects:
Aged
Angiogenesis inhibitors
Antibodies
Antigens
Bevacizumab
Brain
Brain cancer
Brain metastases
Brain Neoplasms - secondary
Brain Neoplasms - therapy
Brain tumors
Cancer
Cancer metastasis
Cancer therapies
Carcinoma
Care and treatment
Case Report
Case reports
Case studies
Causes of
Classification
Diagnosis
Edema
Endothelial growth factors
Family medical history
Gastro-intestinal tract metastases
Gastrointestinal cancer
Gastrointestinal Neoplasms - secondary
Gastrointestinal Neoplasms - therapy
Gastrointestinal system
Guidelines
Humans
Hypotheses
Immunotherapy
Intestine
Kinases
Literature reviews
Male
Malignant meningioma
Medical prognosis
Medicine
Medicine & Public Health
Melanoma
Meningeal Neoplasms - pathology
Meningeal Neoplasms - therapy
Meningioma
Meningioma - pathology
Meningioma - therapy
Metastases
Metastasis
Monoclonal antibodies
Mutation
Neoplasm Grading
Nervous system
NMR
Nuclear magnetic resonance
Patient outcomes
Patients
Phenols (Class of compounds)
Platelet-derived growth factor
Protein-tyrosine kinase
Radiation therapy
Radiotherapy
Recurrence (Disease)
Somatostatin
Surgery
Surgical Oncology
Systemic treatment
Targeted cancer therapy
Tumors
Tyrosine
Vascular endothelial growth factor
Vascular endothelial growth factor receptors
France
United States > US
Systemic treatment
Brain metastases
Malignant meningioma
Gastro-intestinal tract metastases
Bevacizumab
ISSN:1477-7819, 1477-7819
Online Access:Get full text
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Summary:Background Meningioma is the most common adult primary intracranial tumor. Malignant meningioma is a rare variant of meningioma. The prognosis for the patients with these tumors is poor, due to the tumor’s capacity for relapse and to develop distant metastases. These tumors can present the same evolutionary course as aggressive carcinoma. Case description We report the case of distant brain and gastro-intestinal tract (GIT) metastases. A 78-year-old patient developed malignant meningioma with a Ki-67 proliferative index of 40%. According to guidelines, surgery followed by postoperative radiotherapy (RT) was performed. Three months after the end of RT, he presented histologically proven meningioma distant brain and GIT metastases. Conclusions To our knowledge, this is the first case of meningioma GIT metastases. Also, we report the difficulty to confirm the diagnosis of meningioma metastases. Indeed, malignant meningioma has the same histopathological features as melanoma or carcinoma. The standard of care for the management of malignant meningioma is gross total surgery followed by postoperative radiotherapy. Metastatic meningioma is uncommon and no guidelines for the management of recurrent or metastatic meningioma have yet been published. However, several studies reported systemic therapeutic options such as antibody against VEGF, somatostatin analogs, PDGF-R, and VEGF-R tyrosine kinase inhibitors, in the case of recurrent or metastatic meningioma. We also made a review of the actual literature of systemic treatment options for metastatic meningioma.
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ISSN:1477-7819
1477-7819
DOI:10.1186/s12957-019-1596-6