Grade III meningioma with gastro-intestinal tract and brain metastases: case report and review of the literature

Background Meningioma is the most common adult primary intracranial tumor. Malignant meningioma is a rare variant of meningioma. The prognosis for the patients with these tumors is poor, due to the tumor’s capacity for relapse and to develop distant metastases. These tumors can present the same evol...

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Vydané v:	World journal of surgical oncology Ročník 17; číslo 1; s. 70 - 8
Hlavní autori:	Bender, Laura, Lhermitte, Benoit, Carinato, Hélène, Baloglu, Seyyid, Helali, Mehdi, Cebula, Hélène, Antoni, Delphine, Noel, Georges
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London BioMed Central 16.04.2019 BioMed Central Ltd BMC
Predmet:	Aged Angiogenesis inhibitors Antibodies Antigens Bevacizumab Brain Brain cancer Brain metastases Brain Neoplasms - secondary Brain Neoplasms - therapy Brain tumors Cancer Cancer metastasis Cancer therapies Carcinoma Care and treatment Case Report Case reports Case studies Causes of Classification Diagnosis Edema Endothelial growth factors Family medical history Gastro-intestinal tract metastases Gastrointestinal cancer Gastrointestinal Neoplasms - secondary Gastrointestinal Neoplasms - therapy Gastrointestinal system Guidelines Humans Hypotheses Immunotherapy Intestine Kinases Literature reviews Male Malignant meningioma Medical prognosis Medicine Medicine & Public Health Melanoma Meningeal Neoplasms - pathology Meningeal Neoplasms - therapy Meningioma Meningioma - pathology Meningioma - therapy Metastases Metastasis Monoclonal antibodies Mutation Neoplasm Grading Nervous system NMR Nuclear magnetic resonance Patient outcomes Patients Phenols (Class of compounds) Platelet-derived growth factor Protein-tyrosine kinase Radiation therapy Radiotherapy Recurrence (Disease) Somatostatin Surgery Surgical Oncology Systemic treatment Targeted cancer therapy Tumors Tyrosine Vascular endothelial growth factor Vascular endothelial growth factor receptors France United States > US Systemic treatment Brain metastases Malignant meningioma Gastro-intestinal tract metastases Bevacizumab
ISSN:	1477-7819, 1477-7819
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Popis
Shrnutí:	Background Meningioma is the most common adult primary intracranial tumor. Malignant meningioma is a rare variant of meningioma. The prognosis for the patients with these tumors is poor, due to the tumor’s capacity for relapse and to develop distant metastases. These tumors can present the same evolutionary course as aggressive carcinoma. Case description We report the case of distant brain and gastro-intestinal tract (GIT) metastases. A 78-year-old patient developed malignant meningioma with a Ki-67 proliferative index of 40%. According to guidelines, surgery followed by postoperative radiotherapy (RT) was performed. Three months after the end of RT, he presented histologically proven meningioma distant brain and GIT metastases. Conclusions To our knowledge, this is the first case of meningioma GIT metastases. Also, we report the difficulty to confirm the diagnosis of meningioma metastases. Indeed, malignant meningioma has the same histopathological features as melanoma or carcinoma. The standard of care for the management of malignant meningioma is gross total surgery followed by postoperative radiotherapy. Metastatic meningioma is uncommon and no guidelines for the management of recurrent or metastatic meningioma have yet been published. However, several studies reported systemic therapeutic options such as antibody against VEGF, somatostatin analogs, PDGF-R, and VEGF-R tyrosine kinase inhibitors, in the case of recurrent or metastatic meningioma. We also made a review of the actual literature of systemic treatment options for metastatic meningioma.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Case Study-2 ObjectType-Review-5 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1477-7819 1477-7819
DOI:	10.1186/s12957-019-1596-6