Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease

Using a polygenic score of DNA sequence polymorphisms, the authors of this study quantified genetic risk and assessed four healthy lifestyle factors. Among participants at high genetic risk, a healthy lifestyle was associated with a reduced risk of coronary disease. Both genetic and lifestyle factor...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 375; no. 24; pp. 2349 - 2358
Main Authors:	Khera, Amit V, Emdin, Connor A, Drake, Isabel, Natarajan, Pradeep, Bick, Alexander G, Cook, Nancy R, Chasman, Daniel I, Baber, Usman, Mehran, Roxana, Rader, Daniel J, Fuster, Valentin, Boerwinkle, Eric, Melander, Olle, Orho-Melander, Marju, Ridker, Paul M, Kathiresan, Sekar
Format:	Journal Article
Language:	English
Published:	United States Massachusetts Medical Society 15.12.2016
Subjects:	Aged Arteriosclerosis Calcification (ectopic) Cancer Cardiology and Cardiovascular Disease Cardiovascular disease Clinical Medicine Cohort Studies Coronary artery Coronary Disease - epidemiology Coronary Disease - genetics Coronary Disease - prevention & control Coronary vessels Cross-Sectional Studies Diet Female Genetic Predisposition to Disease Genetics Genomes Health risk assessment Healthy Lifestyle Heart diseases Humans Incidence Kardiologi och kardiovaskulära sjukdomar Klinisk medicin Lifestyles Male Medical and Health Sciences Medicin och hälsovetenskap Middle Aged Multifactorial Inheritance Nucleotide sequence Patient Compliance Physical activity Polymorphism, Genetic Risk Risk factors Smoking United States > US Massachusetts
ISSN:	0028-4793, 1533-4406, 1533-4406
Online Access:	Get full text
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