Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease

Using a polygenic score of DNA sequence polymorphisms, the authors of this study quantified genetic risk and assessed four healthy lifestyle factors. Among participants at high genetic risk, a healthy lifestyle was associated with a reduced risk of coronary disease. Both genetic and lifestyle factor...

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Published in:The New England journal of medicine Vol. 375; no. 24; pp. 2349 - 2358
Main Authors: Khera, Amit V, Emdin, Connor A, Drake, Isabel, Natarajan, Pradeep, Bick, Alexander G, Cook, Nancy R, Chasman, Daniel I, Baber, Usman, Mehran, Roxana, Rader, Daniel J, Fuster, Valentin, Boerwinkle, Eric, Melander, Olle, Orho-Melander, Marju, Ridker, Paul M, Kathiresan, Sekar
Format: Journal Article
Language:English
Published: United States Massachusetts Medical Society 15.12.2016
Subjects:
Aged
Arteriosclerosis
Calcification (ectopic)
Cancer
Cardiology and Cardiovascular Disease
Cardiovascular disease
Clinical Medicine
Cohort Studies
Coronary artery
Coronary Disease - epidemiology
Coronary Disease - genetics
Coronary Disease - prevention & control
Coronary vessels
Cross-Sectional Studies
Diet
Female
Genetic Predisposition to Disease
Genetics
Genomes
Health risk assessment
Healthy Lifestyle
Heart diseases
Humans
Incidence
Kardiologi och kardiovaskulära sjukdomar
Klinisk medicin
Lifestyles
Male
Medical and Health Sciences
Medicin och hälsovetenskap
Middle Aged
Multifactorial Inheritance
Nucleotide sequence
Patient Compliance
Physical activity
Polymorphism, Genetic
Risk
Risk factors
Smoking
United States > US
Massachusetts
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Summary:Using a polygenic score of DNA sequence polymorphisms, the authors of this study quantified genetic risk and assessed four healthy lifestyle factors. Among participants at high genetic risk, a healthy lifestyle was associated with a reduced risk of coronary disease. Both genetic and lifestyle factors are key drivers of coronary artery disease, a complex disorder that is the leading cause of death worldwide. 1 A familial pattern in the risk of coronary artery disease was first described in 1938 and was subsequently confirmed in large studies involving twins and prospective cohorts. 2 – 6 Since 2007, genomewide association analyses have identified more than 50 independent loci associated with the risk of coronary artery disease. 7 – 15 These risk alleles, when aggregated into a polygenic risk score, are predictive of incident coronary events and provide a continuous and quantitative measure of genetic susceptibility. 16 – 24 Much . . .
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Drs. Khera and Emdin contributed equally to this article.
ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1605086