Beyond microRNA – Novel RNAs derived from small non-coding RNA and their implication in cancer

► SnoRNAs and tRNAs are specifically processed to different, functional types of smaller RNAs referred to as sdRNAs and tRFs. ► The expression of many snoRNAs, tRNAs, and derived from them smaller RNAs is altered in human disease and cancer. ► SdRNAs and tRFs share components of the molecular pathwa...

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Vydané v:	Cancer letters Ročník 340; číslo 2; s. 201 - 211
Hlavní autori:	Martens-Uzunova, Elena S., Olvedy, Michael, Jenster, Guido
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Ireland Elsevier Ireland Ltd 01.11.2013 Elsevier Limited
Predmet:	Animals Apoptosis Biomarkers, Tumor Biomarkers, Tumor - genetics Cancer Cell growth Deoxyribonucleic acid diagnosis DNA DNA methylation Evolution, Molecular Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Genetic Predisposition to Disease Genetic Testing genetics Genome, Human Genomes Genomics Genomics - methods Hematology, Oncology and Palliative Medicine High-Throughput Nucleotide Sequencing Humans metabolism methods microRNA MicroRNAs MicroRNAs - metabolism Mitochondrial DNA Neoplasms Neoplasms - diagnosis Neoplasms - genetics Neoplasms - therapy Next generation sequencing Non-coding RNA Oligonucleotide Array Sequence Analysis Phenotype Predictive Value of Tests Prognosis Proteins RNA polymerase RNA, Neoplasm RNA, Neoplasm - metabolism RNA, Small Nucleolar RNA, Small Nucleolar - metabolism RNA, Small Untranslated RNA, Small Untranslated - metabolism RNA, Transfer RNA, Transfer - metabolism Sequence Analysis, RNA snoRNA-derived RNA (sdRNA) Technological change Telomerase therapy transcriptome Transfer RNA tRNA fragment (tRF) snoRNA-derived RNA (sdRNA) microRNA Next generation sequencing Non-coding RNA tRNA fragment (tRF) Cancer
ISSN:	0304-3835, 1872-7980, 1872-7980
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Shrnutí:	► SnoRNAs and tRNAs are specifically processed to different, functional types of smaller RNAs referred to as sdRNAs and tRFs. ► The expression of many snoRNAs, tRNAs, and derived from them smaller RNAs is altered in human disease and cancer. ► SdRNAs and tRFs share components of the molecular pathways of RNAi and may function in gene regulation or stress signaling. ► SnoRNAs, tRNAs, and derived from them smaller RNAs are potential oncogenes or tumor suppressor genes. ► SdRNAs and tRFs may provide new perspectives for the development of novel biomarkers and therapeutic strategies in cancer. Over the recent years, Next Generation Sequencing (NGS) technologies targeting the microRNA transcriptome revealed the existence of many different RNA fragments derived from small RNA species other than microRNA. Although initially discarded as RNA turnover artifacts, accumulating evidence suggests that RNA fragments derived from small nucleolar RNA (snoRNA) and transfer RNA (tRNA) are not just random degradation products but rather stable entities, which may have functional activity in the normal and malignant cell. This review summarizes new findings describing the detection and alterations in expression of snoRNA-derived (sdRNA) and tRNA-derived (tRF) RNAs. We focus on the possible interactions of sdRNAs and tRFs with the canonical microRNA pathways in the cell and present current hypotheses on the function of these RNAs.
Bibliografia:	http://dx.doi.org/10.1016/j.canlet.2012.11.058 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0304-3835 1872-7980 1872-7980
DOI:	10.1016/j.canlet.2012.11.058