Measles Immune Suppression: Functional Impairment or Numbers Game?

Resolution of MV infection is associated with increased lymphoproliferation [8], [24] and enlargement of lymph nodes [13]. [...]the immune system efficiently restricts MV replication and clears MV-infected cells. Do Dendritic Dells Play a Crucial Role? DC subsets have been shown susceptible to MV...

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Vydané v:	PLoS pathogens Ročník 10; číslo 12; s. e1004482
Hlavní autori:	de Vries, Rory D., de Swart, Rik L.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 01.12.2014 Public Library of Science (PLoS)
Predmet:	Biology and life sciences Cell Proliferation - physiology Cytotoxicity Dendritic Cells - pathology Dendritic Cells - physiology Host-parasite relationships Humans Immune response Immune system Immune Tolerance - immunology Immunological research Infections Lymphocytes Lymphocytes - pathology Lymphocytes - physiology Measles Measles - immunology Measles - pathology Measles - physiopathology Measles virus - pathogenicity Medical research Medicine and Health Sciences Mortality Opinion Opportunistic Infections - epidemiology Opportunistic Infections - immunology Prevention Risk Factors Studies Virus research
ISSN:	1553-7374, 1553-7366, 1553-7374
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Shrnutí:	Resolution of MV infection is associated with increased lymphoproliferation [8], [24] and enlargement of lymph nodes [13]. [...]the immune system efficiently restricts MV replication and clears MV-infected cells. Do Dendritic Dells Play a Crucial Role? DC subsets have been shown susceptible to MV infection in vitro [15]-[17] and in nonhuman primates in vivo [11], [19]. [...]it is likely that infection, depletion, or functional modulation of DCs contributes to measles-associated immune suppression.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 The authors have declared that no competing interests exist.
ISSN:	1553-7374 1553-7366 1553-7374
DOI:	10.1371/journal.ppat.1004482