Measles Immune Suppression: Functional Impairment or Numbers Game?

  Resolution of MV infection is associated with increased lymphoproliferation [8], [24] and enlargement of lymph nodes [13]. [...]the immune system efficiently restricts MV replication and clears MV-infected cells. Do Dendritic Dells Play a Crucial Role? DC subsets have been shown susceptible to MV...

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Bibliographic Details
Published in:PLoS pathogens Vol. 10; no. 12; p. e1004482
Main Authors: de Vries, Rory D., de Swart, Rik L.
Format: Journal Article
Language:English
Published: United States Public Library of Science 01.12.2014
Public Library of Science (PLoS)
Subjects:
Biology and life sciences
Cell Proliferation - physiology
Cytotoxicity
Dendritic Cells - pathology
Dendritic Cells - physiology
Host-parasite relationships
Humans
Immune response
Immune system
Immune Tolerance - immunology
Immunological research
Infections
Lymphocytes
Lymphocytes - pathology
Lymphocytes - physiology
Measles
Measles - immunology
Measles - pathology
Measles - physiopathology
Measles virus - pathogenicity
Medical research
Medicine and Health Sciences
Mortality
Opinion
Opportunistic Infections - epidemiology
Opportunistic Infections - immunology
Prevention
Risk Factors
Studies
Virus research
ISSN:1553-7374, 1553-7366, 1553-7374
Online Access:Get full text
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Summary:  Resolution of MV infection is associated with increased lymphoproliferation [8], [24] and enlargement of lymph nodes [13]. [...]the immune system efficiently restricts MV replication and clears MV-infected cells. Do Dendritic Dells Play a Crucial Role? DC subsets have been shown susceptible to MV infection in vitro [15]-[17] and in nonhuman primates in vivo [11], [19]. [...]it is likely that infection, depletion, or functional modulation of DCs contributes to measles-associated immune suppression.
Bibliography:ObjectType-Article-1
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ObjectType-Feature-2
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The authors have declared that no competing interests exist.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1004482