Integrating Hi-C links with assembly graphs for chromosome-scale assembly

Long-read sequencing and novel long-range assays have revolutionized de novo genome assembly by automating the reconstruction of reference-quality genomes. In particular, Hi-C sequencing is becoming an economical method for generating chromosome-scale scaffolds. Despite its increasing popularity, th...

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Bibliographic Details
Published in:	PLoS computational biology Vol. 15; no. 8; p. e1007273
Main Authors:	Ghurye, Jay, Rhie, Arang, Walenz, Brian P., Schmitt, Anthony, Selvaraj, Siddarth, Pop, Mihai, Phillippy, Adam M., Koren, Sergey
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.08.2019 Public Library of Science (PLoS)
Subjects:	Algorithms Animals Assembly Bioinformatics Biology and Life Sciences Biosynthesis Chromosome number Chromosome replication Chromosomes Chromosomes, Human - genetics Computational Biology Computer and Information Sciences Computer science Computer Simulation Databases, Nucleic Acid - statistics & numerical data DNA sequencing Gene sequencing Genome, Human Genomes Genomic Library Genomics Genomics - methods Genomics - statistics & numerical data High-Throughput Nucleotide Sequencing - methods High-Throughput Nucleotide Sequencing - statistics & numerical data Humans Informatics Inversions Methods Open source software Research and Analysis Methods Scaffolding Sequence Analysis, DNA - methods Sequence Analysis, DNA - statistics & numerical data Software Source code Technology application Whole genome sequencing United States United States > US Maryland California
ISSN:	1553-7358, 1553-734X, 1553-7358
Online Access:	Get full text
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