Heart valve sclerosis predicts all-cause and cardiovascular mortality

Aortic valve sclerosis (AVS) and mitral annulus calcification (MAC) might predict future adverse events. We undertook the present study to investigate the association of AVS and MAC with all-cause and cardiovascular mortality. We further studied whether a combined presence of AVS and MAC is more str...

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Vydáno v:Atherosclerosis Ročník 209; číslo 2; s. 606 - 610
Hlavní autoři: Völzke, Henry, Haring, Robin, Lorbeer, Roberto, Wallaschofski, Henri, Reffelmann, Thorsten, Empen, Klaus, Rettig, Rainer, John, Ulrich, Felix, Stephan B., Dörr, Marcus
Médium: Journal Article
Jazyk:angličtina
Vydáno: Amsterdam Elsevier Ireland Ltd 01.04.2010
Elsevier
Témata:
Aged
Aortic Valve - pathology
Aortic valve sclerosis
Atherosclerosis
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Calcinosis - complications
Calcinosis - mortality
Cardiology. Vascular system
Cardiovascular
Cardiovascular Diseases - mortality
Cause of Death
Echocardiography
Epidemiology
Female
Germany - epidemiology
Heart Valve Diseases - diagnostic imaging
Heart Valve Diseases - mortality
Heart Valve Diseases - pathology
Humans
Male
Medical sciences
Middle Aged
Mitral annulus calcification
Mitral Valve - pathology
Mortality
Neuropharmacology
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Sclerosis
Mitral annulus calcification
Aortic valve sclerosis
Epidemiology
Mortality
Atherosclerosis
Vascular disease
Calcification
Cardiovascular disease
Heart valve
Aortic valve
ISSN:0021-9150, 1879-1484, 1879-1484
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Shrnutí:Aortic valve sclerosis (AVS) and mitral annulus calcification (MAC) might predict future adverse events. We undertook the present study to investigate the association of AVS and MAC with all-cause and cardiovascular mortality. We further studied whether a combined presence of AVS and MAC is more strongly associated with mortality than the single items and sought to disclose possible gender differences in the investigated associations. We used data from 2081 participants aged ≥45 years (1063 women) of the Study of Health in Pomerania (SHIP). AVS and MAC were determined echocardiographically, and a heart valve sclerosis score was calculated by summing up the AVS and MAC variables. The median duration of mortality follow-up was 8.6 years (17,162 person-years). There were 528 subjects (25.4%) with isolated AVS, 35 with isolated MAC (1.7%) and 89 with both AVS and MAC (4.3%). A total number of 228 deaths (11.0%) occurred during follow-up, including 133 (21.6%) with AVS and 95 subjects (6.5%) without AVS (incidence rate ratio 3.49, 95% CI 2.77; 4.40, p < 0.001). Likewise, mortality rates were higher for subjects with MAC than subjects without MAC (incidence rate ratio 3.79, 95% CI 2.82; 5.02, p < 0.001). Multivariable analyses revealed that the associations of AVS and MAC with all-cause and cardiovascular mortality were independent of major confounders and strongest for highest values of the heart valve sclerosis score. AVS-related mortality was more pronounced in women than in men. AVS and MAC are associated with all-cause and cardiovascular mortality. The association between AVS and mortality is gender-specific with women with AVS being at a higher mortality risk than men with AVS. The summation of AVS and MAC to a heart valve sclerosis score improves the predictability with respect to mortality.
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ISSN:0021-9150
1879-1484
1879-1484
DOI:10.1016/j.atherosclerosis.2009.10.030