Lactate in the tumour microenvironment: From immune modulation to therapy

Disordered metabolic states, which are characterised by hypoxia and elevated levels of metabolites, particularly lactate, contribute to the immunosuppression in the tumour microenvironment (TME). Excessive lactate secreted by metabolism-reprogrammed cancer cells regulates immune responses via causin...

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Bibliographic Details
Published in:	EBioMedicine Vol. 73; p. 103627
Main Authors:	Wang, Zi-Hao, Peng, Wen-Bei, Zhang, Pei, Yang, Xiang-Ping, Zhou, Qiong
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.11.2021 Elsevier
Subjects:	Advanced Basic Science Animals Biological Transport Biomarkers Cancer immunity Cancer metabolism Disease Management Disease Susceptibility Energy Metabolism Glycolysis Glycolytic enzymes Humans Immunomodulation Immunotherapy Internal Medicine Lactate Lactic Acid - metabolism Metabolic Networks and Pathways Monocarboxylate transporters Neoplasms - etiology Neoplasms - metabolism Neoplasms - pathology Neoplasms - therapy Review Tumor Microenvironment - immunology Tumour microenvironment Lactate Monocarboxylate transporters Cancer metabolism Cancer immunity Glycolytic enzymes Tumour microenvironment
ISSN:	2352-3964, 2352-3964
Online Access:	Get full text
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