Lactate in the tumour microenvironment: From immune modulation to therapy

Disordered metabolic states, which are characterised by hypoxia and elevated levels of metabolites, particularly lactate, contribute to the immunosuppression in the tumour microenvironment (TME). Excessive lactate secreted by metabolism-reprogrammed cancer cells regulates immune responses via causin...

Full description

Saved in:
Bibliographic Details
Published in:EBioMedicine Vol. 73; p. 103627
Main Authors: Wang, Zi-Hao, Peng, Wen-Bei, Zhang, Pei, Yang, Xiang-Ping, Zhou, Qiong
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01.11.2021
Elsevier
Subjects:
Advanced Basic Science
Animals
Biological Transport
Biomarkers
Cancer immunity
Cancer metabolism
Disease Management
Disease Susceptibility
Energy Metabolism
Glycolysis
Glycolytic enzymes
Humans
Immunomodulation
Immunotherapy
Internal Medicine
Lactate
Lactic Acid - metabolism
Metabolic Networks and Pathways
Monocarboxylate transporters
Neoplasms - etiology
Neoplasms - metabolism
Neoplasms - pathology
Neoplasms - therapy
Review
Tumor Microenvironment - immunology
Tumour microenvironment
Lactate
Monocarboxylate transporters
Cancer metabolism
Cancer immunity
Glycolytic enzymes
Tumour microenvironment
ISSN:2352-3964, 2352-3964
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Disordered metabolic states, which are characterised by hypoxia and elevated levels of metabolites, particularly lactate, contribute to the immunosuppression in the tumour microenvironment (TME). Excessive lactate secreted by metabolism-reprogrammed cancer cells regulates immune responses via causing extracellular acidification, acting as an energy source by shuttling between different cell populations, and inhibiting the mechanistic (previously ‘mammalian’) target of rapamycin (mTOR) pathway in immune cells. This review focuses on recent advances in the regulation of immune responses by lactate, as well as therapeutic strategies targeting lactate anabolism and transport in the TME, such as those involving glycolytic enzymes and monocarboxylate transporter inhibitors. Considering the multifaceted roles of lactate in cancer metabolism, a comprehensive understanding of how lactate and lactate-targeting therapies regulate immune responses in the TME will provide insights into the complex relationships between metabolism and antitumour immunity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
These authors contributed equally to this review.
ISSN:2352-3964
2352-3964
DOI:10.1016/j.ebiom.2021.103627