Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

Cellular senescence is a key mechanism that drives age-related diseases, but has yet to be targeted therapeutically in humans. Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal cellular senescence-associated disease. Selectively ablating senescent cells using dasatinib plus quercetin (DQ)...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	EBioMedicine Ročník 40; s. 554 - 563
Hlavní autori:	Justice, Jamie N., Nambiar, Anoop M., Tchkonia, Tamar, LeBrasseur, Nathan K., Pascual, Rodolfo, Hashmi, Shahrukh K., Prata, Larissa, Masternak, Michal M., Kritchevsky, Stephen B., Musi, Nicolas, Kirkland, James L.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Netherlands Elsevier B.V 01.02.2019 Elsevier
Predmet:	Advanced Basic Science Aging Cellular senescence Clinical trial Idiopathic pulmonary fibrosis Internal Medicine Interstitial lung disease Research paper Senolytics Translation Translation Idiopathic pulmonary fibrosis Cellular senescence Aging Clinical trial Senolytics Interstitial lung disease
ISSN:	2352-3964, 2352-3964
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Buďte prvý, kto okomentuje tento záznam!