Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis

Increasing evidence highlights dietary fructose as a major driver of non-alcoholic fatty liver disease (NAFLD) pathogenesis, the majority of which is cleared on first pass through the hepatic circulation by enzymatic phosphorylation to fructose-1-phosphate via the ketohexokinase (KHK) enzyme. Withou...

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Bibliographic Details
Published in:	JHEP reports Vol. 3; no. 2; p. 100217
Main Authors:	Shepherd, Emma L., Saborano, Raquel, Northall, Ellie, Matsuda, Kae, Ogino, Hitomi, Yashiro, Hiroaki, Pickens, Jason, Feaver, Ryan E., Cole, Banumathi K., Hoang, Stephen A., Lawson, Mark J., Olson, Matthew, Figler, Robert A., Reardon, John E., Nishigaki, Nobuhiro, Wamhoff, Brian R., Günther, Ulrich L., Hirschfield, Gideon, Erion, Derek M., Lalor, Patricia F.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.04.2021 Elsevier
Subjects:	Fibrosis Fructose Gastroenterology and Hepatology Metabolism NAFLD NASH Treatment NAFLD DNL TIMP-1 TGFB aLMF ALT KHK PBC BSA FIB4 LGLI WT BEC PSC AST KO IGF Metabolism NASH Fructose CT Treatment TG NPCs PDGF Fibrosis HSECs APRI ALD HSCs HSQC G/F platelet-derived growth factor de novo lipogenesis Tissue Inhibitor of Matrix metalloproteinase-1 heteronuclear single quantum coherence insulin-like growth factor non-parenchymal cells hepatic stellate cells fibrosis-4 ketohexokinase bovine serum albumin primary biliary cholangitis primary sclerosing cholangitis non-alcoholic steatohepatitis triglyceride non-alcoholic fatty liver disease transforming growth factor beta glucose/fructose alcohol-related cirrhosis biliary epithelial cells alanine transaminase AST to Platelet Ratio Index computed tomography knockout activated liver myofibroblasts hepatic sinusoidal endothelial cells low glucose and insulin aspartate transaminase wild-type HSQC, heteronuclear single quantum coherence APRI, AST to Platelet Ratio Index DNL, de novo lipogenesis WT, wild-type CT, computed tomography TGFB, transforming growth factor beta aLMF, activated liver myofibroblasts TG, triglyceride NAFLD, non-alcoholic fatty liver disease IGF, insulin-like growth factor HSECs, hepatic sinusoidal endothelial cells BSA, bovine serum albumin NASH, non-alcoholic steatohepatitis KHK, ketohexokinase NPCs, non-parenchymal cells TIMP-1, Tissue Inhibitor of Matrix metalloproteinase-1 FIB4, fibrosis-4 AST, aspartate transaminase ALT, alanine transaminase KO, knockout BEC, biliary epithelial cells HSCs, hepatic stellate cells PSC, primary sclerosing cholangitis G/F, glucose/fructose ALD, alcohol-related cirrhosis LGLI, low glucose and insulin PBC, primary biliary cholangitis PDGF, platelet-derived growth factor
ISSN:	2589-5559, 2589-5559
Online Access:	Get full text
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