SARS-CoV-2 spike protein S1 subunit induces pro-inflammatory responses via toll-like receptor 4 signaling in murine and human macrophages

Coronavirus disease 2019 (COVID-19), an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has now spread globally. Some patients develop severe complications including multiple organ failure. It has been suggested that excessive inflammation associated with t...

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Bibliographic Details
Published in:	Heliyon Vol. 7; no. 2; p. e06187
Main Authors:	Shirato, Ken, Kizaki, Takako
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.02.2021 Elsevier
Subjects:	antagonists COVID-19 infection cytokines humans Inflammation lipopolysaccharides Macrophage macrophages mice mitogen-activated protein kinase mortality S1 subunit SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Spike protein Toll-like receptor 4 SARS-CoV-2 Inflammation Spike protein Toll-like receptor 4 S1 subunit Macrophage
ISSN:	2405-8440, 2405-8440
Online Access:	Get full text
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