Erlotinib added to carboplatin and paclitaxel as first-line treatment of ovarian cancer: A phase II study based on surgical reassessment

The purpose of this study was to determine whether adding the anti-epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib to carboplatin/paclitaxel improved pathologic complete response (pCR) at reassessment surgery in epithelial ovarian, fallopian tube, or primary peritoneal ca...

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Bibliographic Details
Published in:	Gynecologic oncology Vol. 119; no. 3; pp. 451 - 456
Main Authors:	Blank, Stephanie V., Christos, Paul, Curtin, John P., Goldman, Noah, Runowicz, Carolyn D., Sparano, Joseph A., Liebes, Leonard, Chen, Helen X., Muggia, Franco M.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.12.2010
Subjects:	Adult Aged Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Carboplatin Carboplatin - administration & dosage Carboplatin - adverse effects Chemotherapy, Adjuvant Disease-Free Survival ErbB Receptors - antagonists & inhibitors ErbB Receptors - genetics Erlotinib Erlotinib Hydrochloride Fallopian Tube Neoplasms - drug therapy Fallopian Tube Neoplasms - genetics Fallopian Tube Neoplasms - pathology Fallopian Tube Neoplasms - surgery Female Gene Amplification - drug effects Genes, erbB-1 - drug effects Hematology, Oncology and Palliative Medicine Humans Middle Aged Neoadjuvant Therapy Neoplasm Staging Obstetrics and Gynecology Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Ovarian Neoplasms - surgery Paclitaxel Paclitaxel - administration & dosage Paclitaxel - adverse effects Peritoneal Neoplasms - drug therapy Peritoneal Neoplasms - genetics Peritoneal Neoplasms - pathology Peritoneal Neoplasms - surgery Quinazolines - administration & dosage Quinazolines - adverse effects Reassessment surgery Young Adult Carboplatin Reassessment surgery Erlotinib Paclitaxel Ovarian cancer
ISSN:	0090-8258, 1095-6859, 1095-6859
Online Access:	Get full text
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