HCV-Related Nervous System Disorders

Chronic infection with hepatitis C virus (HCV) is associated with a wide spectrum of extrahepatic manifestations, affecting different organ systems. Neurological complications occur in a large number of patients and range from peripheral neuropathy to cognitive impairment. Pathogenetic mechanisms re...

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Bibliographic Details
Published in:Clinical & developmental immunology Vol. 2012; no. 2012; pp. 1 - 9
Main Authors: Zanusso, Gianluigi, Ferrari, Sergio, Gajofatto, Alberto, Mariotto, Sara, Monaco, Salvatore
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Puplishing Corporation 01.01.2012
Hindawi Publishing Corporation
John Wiley & Sons, Inc
Wiley
Subjects:
Antigen-antibody complexes
Autoimmune Diseases - complications
Autoimmune Diseases - etiology
Autoimmune Diseases - virology
Hepacivirus - physiology
Hepatitis C virus
Hepatitis C, Chronic - complications
Hepatitis C, Chronic - virology
Humans
Immunology
Muscular Diseases - etiology
Muscular Diseases - virology
Nervous System Diseases - etiology
Nervous System Diseases - virology
Peripheral Nervous System Diseases - etiology
Peripheral Nervous System Diseases - virology
Review
ISSN:1740-2522, 2314-8861, 1740-2530, 1740-2530, 2314-7156
Online Access:Get full text
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Summary:Chronic infection with hepatitis C virus (HCV) is associated with a wide spectrum of extrahepatic manifestations, affecting different organ systems. Neurological complications occur in a large number of patients and range from peripheral neuropathy to cognitive impairment. Pathogenetic mechanisms responsible for nervous system dysfunction are mainly related to the upregulation of the host immune response with production of autoantibodies, immune complexes, and cryoglobulins. Alternative mechanisms include possible extrahepatic replication of HCV in neural tissues and the effects of circulating inflammatory cytokines and chemokines.
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Academic Editor: Domenico Sansonno
ISSN:1740-2522
2314-8861
1740-2530
1740-2530
2314-7156
DOI:10.1155/2012/236148