HCV-Related Nervous System Disorders

Chronic infection with hepatitis C virus (HCV) is associated with a wide spectrum of extrahepatic manifestations, affecting different organ systems. Neurological complications occur in a large number of patients and range from peripheral neuropathy to cognitive impairment. Pathogenetic mechanisms re...

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Vydané v:	Clinical & developmental immunology Ročník 2012; číslo 2012; s. 1 - 9
Hlavní autori:	Zanusso, Gianluigi, Ferrari, Sergio, Gajofatto, Alberto, Mariotto, Sara, Monaco, Salvatore
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Cairo, Egypt Hindawi Puplishing Corporation 01.01.2012 Hindawi Publishing Corporation John Wiley & Sons, Inc Wiley
Predmet:	Antigen-antibody complexes Autoimmune Diseases - complications Autoimmune Diseases - etiology Autoimmune Diseases - virology Hepacivirus - physiology Hepatitis C virus Hepatitis C, Chronic - complications Hepatitis C, Chronic - virology Humans Immunology Muscular Diseases - etiology Muscular Diseases - virology Nervous System Diseases - etiology Nervous System Diseases - virology Peripheral Nervous System Diseases - etiology Peripheral Nervous System Diseases - virology Review
ISSN:	1740-2522, 2314-8861, 1740-2530, 1740-2530, 2314-7156
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Popis
Shrnutí:	Chronic infection with hepatitis C virus (HCV) is associated with a wide spectrum of extrahepatic manifestations, affecting different organ systems. Neurological complications occur in a large number of patients and range from peripheral neuropathy to cognitive impairment. Pathogenetic mechanisms responsible for nervous system dysfunction are mainly related to the upregulation of the host immune response with production of autoantibodies, immune complexes, and cryoglobulins. Alternative mechanisms include possible extrahepatic replication of HCV in neural tissues and the effects of circulating inflammatory cytokines and chemokines.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 Academic Editor: Domenico Sansonno
ISSN:	1740-2522 2314-8861 1740-2530 1740-2530 2314-7156
DOI:	10.1155/2012/236148