HCV-Related Nervous System Disorders
Chronic infection with hepatitis C virus (HCV) is associated with a wide spectrum of extrahepatic manifestations, affecting different organ systems. Neurological complications occur in a large number of patients and range from peripheral neuropathy to cognitive impairment. Pathogenetic mechanisms re...
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| Vydáno v: | Clinical & developmental immunology Ročník 2012; číslo 2012; s. 1 - 9 |
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| Hlavní autoři: | , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
Cairo, Egypt
Hindawi Puplishing Corporation
01.01.2012
Hindawi Publishing Corporation John Wiley & Sons, Inc Wiley |
| Témata: | |
| ISSN: | 1740-2522, 2314-8861, 1740-2530, 1740-2530, 2314-7156 |
| On-line přístup: | Získat plný text |
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| Shrnutí: | Chronic infection with hepatitis C virus (HCV) is associated with a wide spectrum of extrahepatic manifestations, affecting different organ systems. Neurological complications occur in a large number of patients and range from peripheral neuropathy to cognitive impairment. Pathogenetic mechanisms responsible for nervous system dysfunction are mainly related to the upregulation of the host immune response with production of autoantibodies, immune complexes, and cryoglobulins. Alternative mechanisms include possible extrahepatic replication of HCV in neural tissues and the effects of circulating inflammatory cytokines and chemokines. |
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| Bibliografie: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 Academic Editor: Domenico Sansonno |
| ISSN: | 1740-2522 2314-8861 1740-2530 1740-2530 2314-7156 |
| DOI: | 10.1155/2012/236148 |