Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression

Several studies have proposed that brain glutamate signaling abnormalities and glial pathology have a role in the etiology of major depressive disorder (MDD). These conclusions were primarily drawn from post-mortem studies in which forebrain brain regions were examined. The locus coeruleus (LC) is t...

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Bibliographic Details
Published in:	Molecular psychiatry Vol. 16; no. 6; pp. 634 - 646
Main Authors:	Bernard, R, Kerman, I A, Thompson, R C, Jones, E G, Bunney, W E, Barchas, J D, Schatzberg, A F, Myers, R M, Akil, H, Watson, S J
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.06.2011 Nature Publishing Group
Subjects:	631/208/191/2018 631/378/1385/1611 692/699/476/1414 Adolescent Adult Adult and adolescent clinical studies Aged Antidepressants Astrocytes Autopsy Behavioral Sciences Biological and medical sciences Biological Psychology Bipolar disorder Brain Brain stem Cellular signal transduction Cognitive ability Depression Depressive Disorder, Major - pathology Development and progression DNA microarrays Drugs Emotional disorders Etiology Female Fibroblast growth factor receptors Forebrain Gene expression Gene Expression Profiling - methods Gene Expression Regulation Genetic aspects Glutamate Glutamate Plasma Membrane Transport Proteins Glutamic Acid - genetics Glutamic Acid - metabolism Growth factors Humans Hybridization Innervation Intercellular Signaling Peptides and Proteins Lasers Locus coeruleus Locus Coeruleus - metabolism Locus Coeruleus - pathology Major depressive disorder Male Medical sciences Medicine Medicine & Public Health Mental depression Microdissection Middle Aged Models, Biological Mood disorders Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neuroglia - metabolism Neurosciences Neurotransmission Norepinephrine Oligonucleotide Array Sequence Analysis - methods original-article Pharmacotherapy Physiological aspects Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Risk factors RNA, Messenger - metabolism Signal transduction Signal Transduction - physiology TrkB receptors Young Adult United States Germany Ann Arbor Michigan United States > US California norepinephrine laser-capture microdissection post mortem microarray human monoamine Mood disorder Human Neuroglia Central nervous system Postmortem Monoamine Depression Catecholamine Glutamate Genetic determinism Encephalon Signal transduction Gene Laser Excitatory aminoacid Neurotransmitter Genetics Norepinephrine Locus coeruleus Growth factor growth factor bipolar disorder mood disorder glia locus coeruleus glutamate major depression gene expression
ISSN:	1359-4184, 1476-5578, 1476-5578
Online Access:	Get full text
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