Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

Marco Marra and colleagues identify somatic mutations in EZH2 in diffuse large B-cell lymphomas and follicular lymphomas. EZH2 is a histone methyltransferase that participates in trimethylation of H3 Lys27 (H3K27) as part of the PRC2 complex. The mutations alter a single tyrosine residue in the SET...

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Bibliographic Details
Published in:	Nature genetics Vol. 42; no. 2; pp. 181 - 185
Main Authors:	Morin, Ryan D, Johnson, Nathalie A, Severson, Tesa M, Mungall, Andrew J, An, Jianghong, Goya, Rodrigo, Paul, Jessica E, Boyle, Merrill, Woolcock, Bruce W, Kuchenbauer, Florian, Yap, Damian, Humphries, R Keith, Griffith, Obi L, Shah, Sohrab, Zhu, Henry, Kimbara, Michelle, Shashkin, Pavel, Charlot, Jean F, Tcherpakov, Marianna, Corbett, Richard, Tam, Angela, Varhol, Richard, Smailus, Duane, Moksa, Michelle, Zhao, Yongjun, Delaney, Allen, Qian, Hong, Birol, Inanc, Schein, Jacqueline, Moore, Richard, Holt, Robert, Horsman, Doug E, Connors, Joseph M, Jones, Steven, Aparicio, Samuel, Hirst, Martin, Gascoyne, Randy D, Marra, Marco A
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.02.2010 Nature Publishing Group
Subjects:	631/208/2489/2487/2486 631/250/2502/2170 692/699/67/1990/291 Adult Aged Agriculture Amino Acid Sequence Animal Genetics and Genomics Base Sequence Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Cancer Research Care and treatment Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Crystal structure DNA Mutational Analysis DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics Enhancer of Zeste Homolog 2 Protein Enzymatic activity Exons - genetics Female Fundamental and applied biological sciences. Psychology Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Function Gene mutations Genetic aspects Genome, Human - genetics Germinal Center - metabolism Germinal Center - pathology Health aspects Health services Hematologic and hematopoietic diseases Human Genetics Humans letter Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma Lymphoma, Follicular - genetics Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - pathology Male Medical research Medical sciences Methyltransferases Middle Aged Molecular and cellular biology Molecular Sequence Data Mutant Proteins - chemistry Mutant Proteins - genetics Mutant Proteins - metabolism Mutation Mutation - genetics Non-Hodgkin's lymphomas Physiological aspects Polycomb Repressive Complex 2 Risk factors Transcription Factors - chemistry Transcription Factors - genetics Tyrosine - genetics Canada United States Somatic mutation Origin Germinative center Lymphoproliferative syndrome Diffuse large B cell lymphoma Malignant hemopathy Non Hodgkin lymphoma Cancer
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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