Molecular detection and characterization of human gyroviruses identified in the ferret fecal virome

The recently described novel gyroviruses may infect chickens and/or humans; however, their pathogenic potential is unknown. In our metagenomic investigation, we detected many of the novel gyroviruses in the fecal viromes of ferrets with lymph node and organ enlargement. The complete genomic sequence...

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Bibliographic Details
Published in:Archives of virology Vol. 159; no. 12; pp. 3401 - 3406
Main Authors: Fehér, Enikő, Pazár, Péter, Kovács, Eszter, Farkas, Szilvia L, Lengyel, György, Jakab, Ferenc, Martella, Vito, Bányai, Krisztián
Format: Journal Article
Language:English
Published: Vienna Springer-Verlag 01.12.2014
Springer Vienna
Springer Nature B.V
Subjects:
Anemia
Animals
Biomedical and Life Sciences
Biomedicine
Brief Report
DNA polymerase
DNA, Viral - chemistry
DNA, Viral - genetics
Feces
Feces - virology
ferrets
Ferrets - virology
Genetic testing
Genetic Variation
Genome, Viral
Genomes
Gyrovirus - classification
Gyrovirus - genetics
Gyrovirus - isolation & purification
hosts
humans
Infectious Diseases
lymph nodes
Lymphatic system
Medical Microbiology
metagenomics
Mustela putorius furo
nucleotide sequences
Poultry
Sequence Analysis, DNA
Sequence Homology
Virology
Hungary
Chicken Anaemia Virus
Diagnostic Primer
Homologous Reference
Viral Metagenomics
Fecal Virome
ISSN:0304-8608, 1432-8798, 1432-8798
Online Access:Get full text
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Description
Summary:The recently described novel gyroviruses may infect chickens and/or humans; however, their pathogenic potential is unknown. In our metagenomic investigation, we detected many of the novel gyroviruses in the fecal viromes of ferrets with lymph node and organ enlargement. The complete genomic sequences of selected gyrovirus strains showed 90.7-99.4 % similarity to homologous reference gyrovirus strains. This study did not demonstrate an association between gyrovirus shedding from ferrets and the observed background disease; however, it provides evidence for genetic diversity among gyroviruses and raises the possibility that pet ferrets may transmit gyroviruses to heterologous hosts, e.g., humans.
Bibliography:http://dx.doi.org/10.1007/s00705-014-2203-3
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ISSN:0304-8608
1432-8798
1432-8798
DOI:10.1007/s00705-014-2203-3