Molecular detection and characterization of human gyroviruses identified in the ferret fecal virome

The recently described novel gyroviruses may infect chickens and/or humans; however, their pathogenic potential is unknown. In our metagenomic investigation, we detected many of the novel gyroviruses in the fecal viromes of ferrets with lymph node and organ enlargement. The complete genomic sequence...

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Vydáno v:	Archives of virology Ročník 159; číslo 12; s. 3401 - 3406
Hlavní autoři:	Fehér, Enikő, Pazár, Péter, Kovács, Eszter, Farkas, Szilvia L, Lengyel, György, Jakab, Ferenc, Martella, Vito, Bányai, Krisztián
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Vienna Springer-Verlag 01.12.2014 Springer Vienna Springer Nature B.V
Témata:	Anemia Animals Biomedical and Life Sciences Biomedicine Brief Report DNA polymerase DNA, Viral - chemistry DNA, Viral - genetics Feces Feces - virology ferrets Ferrets - virology Genetic testing Genetic Variation Genome, Viral Genomes Gyrovirus - classification Gyrovirus - genetics Gyrovirus - isolation & purification hosts humans Infectious Diseases lymph nodes Lymphatic system Medical Microbiology metagenomics Mustela putorius furo nucleotide sequences Poultry Sequence Analysis, DNA Sequence Homology Virology Hungary Chicken Anaemia Virus Diagnostic Primer Homologous Reference Viral Metagenomics Fecal Virome
ISSN:	0304-8608, 1432-8798, 1432-8798
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Popis
Shrnutí:	The recently described novel gyroviruses may infect chickens and/or humans; however, their pathogenic potential is unknown. In our metagenomic investigation, we detected many of the novel gyroviruses in the fecal viromes of ferrets with lymph node and organ enlargement. The complete genomic sequences of selected gyrovirus strains showed 90.7-99.4 % similarity to homologous reference gyrovirus strains. This study did not demonstrate an association between gyrovirus shedding from ferrets and the observed background disease; however, it provides evidence for genetic diversity among gyroviruses and raises the possibility that pet ferrets may transmit gyroviruses to heterologous hosts, e.g., humans.
Bibliografie:	http://dx.doi.org/10.1007/s00705-014-2203-3 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0304-8608 1432-8798 1432-8798
DOI:	10.1007/s00705-014-2203-3