The genetics of human ageing

The past two centuries have witnessed an unprecedented rise in human life expectancy. Sustaining longer lives with reduced periods of disability will require an understanding of the underlying mechanisms of ageing, and genetics is a powerful tool for identifying these mechanisms. Large-scale genome-...

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Bibliographic Details
Published in:Nature reviews. Genetics Vol. 21; no. 2; pp. 88 - 101
Main Authors: Melzer, David, Pilling, Luke C, Ferrucci, Luigi
Format: Journal Article
Language:English
Published: England Nature Publishing Group 01.02.2020
Subjects:
Aging
Aging - genetics
Animals
Female
Genetic Predisposition to Disease
Genetic research
Genome-wide association studies
Genome-Wide Association Study
Genomes
Humans
Life span
Longevity - genetics
Mutation
Phenotype
Progeria
Reproduction - genetics
ISSN:1471-0056, 1471-0064, 1471-0064
Online Access:Get full text
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Summary:The past two centuries have witnessed an unprecedented rise in human life expectancy. Sustaining longer lives with reduced periods of disability will require an understanding of the underlying mechanisms of ageing, and genetics is a powerful tool for identifying these mechanisms. Large-scale genome-wide association studies have recently identified many loci that influence key human ageing traits, including lifespan. Multi-trait loci have been linked with several age-related diseases, suggesting shared ageing influences. Mutations that drive accelerated ageing in prototypical progeria syndromes in humans point to an important role for genome maintenance and stability. Together, these different strands of genetic research are highlighting pathways for the discovery of anti-ageing interventions that may be applicable in humans.
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ISSN:1471-0056
1471-0064
1471-0064
DOI:10.1038/s41576-019-0183-6