Air Travel Is Associated with Intracontinental Spread of Dengue Virus Serotypes 1–3 in Brazil

Dengue virus and its four serotypes (DENV-1 to DENV-4) infect 390 million people and are implicated in at least 25,000 deaths annually, with the largest disease burden in tropical and subtropical regions. We investigated the spatial dynamics of DENV-1, DENV-2 and DENV-3 in Brazil by applying a stati...

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Vydané v:PLoS neglected tropical diseases Ročník 8; číslo 4; s. e2769
Hlavní autori: Nunes, Marcio R. T., Palacios, Gustavo, Faria, Nuno Rodrigues, Sousa, Edivaldo Costa, Pantoja, Jamilla A., Rodrigues, Sueli G., Carvalho, Valéria L., Medeiros, Daniele B. A., Savji, Nazir, Baele, Guy, Suchard, Marc A., Lemey, Philippe, Vasconcelos, Pedro F. C., Lipkin, W. Ian
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Public Library of Science 01.04.2014
Public Library of Science (PLoS)
Predmet:
Aedes aegypti
Agreements
Air Travel
Animals
Biology and Life Sciences
Brazil
Brazil - epidemiology
Demographic aspects
Dengue - epidemiology
Dengue - transmission
Dengue - virology
Dengue fever
Dengue virus
Dengue Virus - classification
Dengue Virus - isolation & purification
Dengue viruses
Disease
Disease transmission
Epidemiology
Evolution
Generalized linear models
Genomes
Genotype & phenotype
Geography
Grants
Health aspects
Humans
Medicine and Health Sciences
Methods
Phylogenetics
Phylogeography
Tropical diseases
Brazil
ASW, Caribbean Sea
Caribbean Region
Air Travel
Brazil
Animals
Dengue
Humans
Dengue Virus
ISSN:1935-2735, 1935-2727, 1935-2735
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Shrnutí:Dengue virus and its four serotypes (DENV-1 to DENV-4) infect 390 million people and are implicated in at least 25,000 deaths annually, with the largest disease burden in tropical and subtropical regions. We investigated the spatial dynamics of DENV-1, DENV-2 and DENV-3 in Brazil by applying a statistical framework to complete genome sequences. For all three serotypes, we estimated that the introduction of new lineages occurred within 7 to 10-year intervals. New lineages were most likely to be imported from the Caribbean region to the North and Northeast regions of Brazil, and then to disperse at a rate of approximately 0.5 km/day. Joint statistical analysis of evolutionary, epidemiological and ecological data indicates that aerial transportation of humans and/or vector mosquitoes, rather than Aedes aegypti infestation rates or geographical distances, determine dengue virus spread in Brazil.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Current address: School of Medicine, New York University, New York, New York, United States of America.
Conceived and designed the experiments: MRTN GP NRF. Performed the experiments: MRTN GP NRF ECS JAP VLC NS GB MAS. Analyzed the data: MRTN GP NRF NS GB MAS PL DBAM SGR. Contributed reagents/materials/analysis tools: MRTN GP PFCV GB MAS WIL PL. Wrote the paper: MRTN GP NRF ECS JAP SGR VLC DBAM NS GB MAS PL PFCV WIL.
The authors have declared that no competing interests exist.
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0002769