Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns

As organisms age, cells accumulate genetic and epigenetic errors that eventually lead to impaired organ function or catastrophic transformation such as cancer. Because aging reflects a stochastic process of increasing disorder, cells in an organ will be individually affected in different ways, thus...

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Bibliographic Details
Published in:	Cell Vol. 171; no. 2; p. 321
Main Authors:	Enge, Martin, Arda, H Efsun, Mignardi, Marco, Beausang, John, Bottino, Rita, Kim, Seung K, Quake, Stephen R
Format:	Journal Article
Language:	English
Published:	United States 05.10.2017
Subjects:	Adult Aging - pathology Cellular Senescence Child Child, Preschool Humans Infant Middle Aged Mutation Pancreas - cytology Pancreas - pathology Pancreas - physiology Polymorphism, Single Nucleotide Sequence Analysis, RNA Single-Cell Analysis Transcription, Genetic insulin mutational signatures human aging transcriptional instability glucagon single-cell RNA-seq islet somatic variation human pancreas
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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