Life Extension Factor Klotho Enhances Cognition

Aging is the primary risk factor for cognitive decline, an emerging health threat to aging societies worldwide. Whether anti-aging factors such as klotho can counteract cognitive decline is unknown. We show that a lifespan-extending variant of the human KLOTHO gene, KL-VS, is associated with enhance...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 7; no. 4; pp. 1065 - 1076
Main Authors:	Dubal, Dena B., Yokoyama, Jennifer S., Zhu, Lei, Broestl, Lauren, Worden, Kurtresha, Wang, Dan, Sturm, Virginia E., Kim, Daniel, Klein, Eric, Yu, Gui-Qiu, Ho, Kaitlyn, Eilertson, Kirsten E., Yu, Lei, Kuro-o, Makoto, De Jager, Philip L., Coppola, Giovanni, Small, Gary W., Bennett, David A., Kramer, Joel H., Abraham, Carmela R., Miller, Bruce L., Mucke, Lennart
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.05.2014 Elsevier
Subjects:	Age Factors Aged Aged, 80 and over Animals Cognition - physiology Cohort Studies Female Glucuronidase - genetics Glucuronidase - metabolism Glucuronidase - physiology Humans Klotho Proteins Life Expectancy Male Memory - physiology Mice Mice, Inbred C57BL Mice, Transgenic Middle Aged Receptors, N-Methyl-D-Aspartate - metabolism Synapses - metabolism
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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