Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia

Alterations of IKZF1, encoding the lymphoid transcription factor IKAROS, are a hallmark of high-risk acute lymphoblastic leukemia (ALL), however the role of IKZF1 alterations in ALL pathogenesis is poorly understood. Here, we show that in mouse models of BCR-ABL1 leukemia, Ikzf1 and Arf alterations...

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Veröffentlicht in:	Cancer cell Jg. 28; H. 3; S. 343
Hauptverfasser:	Churchman, Michelle L, Low, Jonathan, Qu, Chunxu, Paietta, Elisabeth M, Kasper, Lawryn H, Chang, Yunchao, Payne-Turner, Debbie, Althoff, Mark J, Song, Guangchun, Chen, Shann-Ching, Ma, Jing, Rusch, Michael, McGoldrick, Dan, Edmonson, Michael, Gupta, Pankaj, Wang, Yong-Dong, Caufield, William, Freeman, Burgess, Li, Lie, Panetta, John C, Baker, Sharyn, Yang, Yung-Li, Roberts, Kathryn G, McCastlain, Kelly, Iacobucci, Ilaria, Peters, Jennifer L, Centonze, Victoria E, Notta, Faiyaz, Dobson, Stephanie M, Zandi, Sasan, Dick, John E, Janke, Laura, Peng, Junmin, Kodali, Kiran, Pagala, Vishwajeeth, Min, Jaeki, Mayasundari, Anand, Williams, Richard T, Willman, Cheryl L, Rowe, Jacob, Luger, Selina, Dickins, Ross A, Guy, R Kiplin, Chen, Taosheng, Mullighan, Charles G
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 14.09.2015
Schlagworte:	Animals Cell Cycle Checkpoints - genetics Fusion Proteins, bcr-abl - genetics Humans Ikaros Transcription Factor - genetics Mice Mutation - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Receptors, Retinoic Acid - metabolism Retinoids - metabolism
ISSN:	1878-3686, 1878-3686
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