Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors

Finding individual-level data for adequatelypowered Mendelian randomization analyses may be problematic. As publicly-available summarized data on genetic associations with disease outcomes from large consortia are becoming more abundant, use of published data is an attractive analysis strategy for o...

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Vydáno v:	European journal of epidemiology Ročník 30; číslo 7; s. 543 - 552
Hlavní autoři:	Burgess, Stephen, Scott, Robert A., Timpson, Nicholas J., Smith, George Davey, Thompson, Simon G.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Dordrecht Springer 01.07.2015 Springer Netherlands Springer Nature B.V
Témata:	Calcium Cardiology Data Interpretation, Statistical Epidemiology Genetic Predisposition to Disease Genetic variance Genetic Variation Humans Infectious Diseases Medicine Medicine & Public Health Mendelian Randomization Analysis - methods METHODS Oncology Public Health Random Allocation Risk Factors Sensitivity and Specificity Statistical methods Instrumental variable Causal inference Summarized data Mendelian randomization Published data Two-sample Mendelian randomization
ISSN:	0393-2990, 1573-7284, 1573-7284
On-line přístup:	Získat plný text
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