Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors

Alzheimer's disease (AD) is an age-dependent neurodegenerative disease that causes progressive cognitive impairment. The initiation and progression of AD has been linked to cholesterol metabolism and inflammation, processes that can be modulated by liver x receptors (LXRs). We show here that en...

Full description

Saved in:

Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 104; no. 25; p. 10601
Main Authors:	Zelcer, Noam, Khanlou, Negar, Clare, Ryan, Jiang, Qingguang, Reed-Geaghan, Erin G, Landreth, Gary E, Vinters, Harry V, Tontonoz, Peter
Format:	Journal Article
Language:	English
Published:	United States 19.06.2007
Subjects:	Alzheimer Disease - pathology Amyloid beta-Peptides - pharmacology Animals Brain - metabolism Brain - pathology Cells, Cultured Cholesterol - genetics Cholesterol - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Fluorescent Antibody Technique, Indirect Gene Expression Regulation - physiology Immunohistochemistry Inflammation - metabolism Inflammation - pathology Lipid Metabolism Liver X Receptors Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Microglia - cytology Microglia - drug effects Microglia - physiology Orphan Nuclear Receptors Phagocytosis - drug effects Phagocytosis - physiology Plaque, Amyloid - pathology Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - physiology Signal Transduction
ISSN:	0027-8424
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!