Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors

Alzheimer's disease (AD) is an age-dependent neurodegenerative disease that causes progressive cognitive impairment. The initiation and progression of AD has been linked to cholesterol metabolism and inflammation, processes that can be modulated by liver x receptors (LXRs). We show here that en...

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Vydáno v:	Proceedings of the National Academy of Sciences - PNAS Ročník 104; číslo 25; s. 10601
Hlavní autoři:	Zelcer, Noam, Khanlou, Negar, Clare, Ryan, Jiang, Qingguang, Reed-Geaghan, Erin G, Landreth, Gary E, Vinters, Harry V, Tontonoz, Peter
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 19.06.2007
Témata:	Alzheimer Disease - pathology Amyloid beta-Peptides - pharmacology Animals Brain - metabolism Brain - pathology Cells, Cultured Cholesterol - genetics Cholesterol - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Fluorescent Antibody Technique, Indirect Gene Expression Regulation - physiology Immunohistochemistry Inflammation - metabolism Inflammation - pathology Lipid Metabolism Liver X Receptors Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Microglia - cytology Microglia - drug effects Microglia - physiology Orphan Nuclear Receptors Phagocytosis - drug effects Phagocytosis - physiology Plaque, Amyloid - pathology Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - physiology Signal Transduction
ISSN:	0027-8424
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