Ex vivo MRI and histopathology detect novel iron-rich cortical inflammation in frontotemporal lobar degeneration with tau versus TDP-43 pathology

[Display omitted] •Comparative study of whole-hemisphere ex vivo T2*-weighted MRI and histopathology.•Sample of FTLD-Tau and FTLD-TDP subtypes with reference to healthy and AD brain.•Novel focal upper cortical-layer iron-rich pathology distinguishes FTLD-TDP from clinically-similar FTLD-Tau and AD.•...

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Vydané v:	NeuroImage clinical Ročník 33; s. 102913
Hlavní autori:	Tisdall, M. Dylan, Ohm, Daniel T., Lobrovich, Rebecca, Das, Sandhitsu R., Mizsei, Gabor, Prabhakaran, Karthik, Ittyerah, Ranjit, Lim, Sydney, McMillan, Corey T., Wolk, David A., Gee, James, Trojanowski, John Q., Lee, Edward B., Detre, John A., Yushkevich, Paul, Grossman, Murray, Irwin, David J.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Netherlands Elsevier Inc 01.01.2022 Elsevier
Predmet:	Alzheimer’s disease DNA-Binding Proteins Ex vivo MRI Frontotemporal Dementia - diagnostic imaging Frontotemporal Dementia - pathology Frontotemporal lobar degeneration Frontotemporal Lobar Degeneration - diagnostic imaging Frontotemporal Lobar Degeneration - pathology Histopathology Humans Inflammation - diagnostic imaging Iron Magnetic Resonance Imaging Radiology Regular tau Proteins Frontotemporal lobar degeneration Ex vivo MRI Iron Histopathology Alzheimer’s disease
ISSN:	2213-1582, 2213-1582
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