A presurgical voxel-wise predictive model for cerebellar mutism syndrome in children with posterior fossa tumors

•Built a voxel-wise predictive model for CMS in patients with posterior fossa tumors.•Bilateral SCP, ICP, the superior cerebellar areas, and brain stem were related to CMS.•Voxels related to CMS presented with a right-lateral pattern of the cerebellum. This study aimed to investigate cerebellar muti...

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Vydáno v:	NeuroImage clinical Ročník 37; s. 103291
Hlavní autoři:	Yang, Wei, Li, Yiming, Ying, Zesheng, Cai, Yingjie, Peng, Xiaojiao, Sun, HaiLang, Chen, Jiashu, Zhu, Kaiyi, Hu, Geli, Peng, Yun, Ge, Ming
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Netherlands Elsevier Inc 01.01.2023 Elsevier
Témata:	Brain Neoplasms - pathology Cerebellar Diseases - diagnostic imaging Cerebellar Diseases - etiology Cerebellar mutism syndrome Cerebellar Neoplasms - complications Cerebellar Neoplasms - diagnostic imaging Cerebellar Neoplasms - surgery Cerebellum Child Humans Infratentorial Neoplasms - diagnostic imaging Infratentorial Neoplasms - surgery Lesion-symptom mapping Mutism - diagnostic imaging Mutism - etiology Predictive model Radiology Regular Retrospective Studies Syndrome Lesion-symptom mapping Cerebellar mutism syndrome Predictive model
ISSN:	2213-1582, 2213-1582
On-line přístup:	Získat plný text
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Popis
Shrnutí:	•Built a voxel-wise predictive model for CMS in patients with posterior fossa tumors.•Bilateral SCP, ICP, the superior cerebellar areas, and brain stem were related to CMS.•Voxels related to CMS presented with a right-lateral pattern of the cerebellum. This study aimed to investigate cerebellar mutism syndrome (CMS)-related voxels and build a voxel-wise predictive model for CMS. From July 2013 to January 2022, 188 pediatric patients diagnosed with posterior fossa tumor were included in this study, including 38 from a prospective cohort recruited between 2020 and January 2022, and the remaining from a retrospective cohort recruited in July 2013-Aug 2020. The retrospective cohort was divided into the training and validation sets; the prospective cohort served as a prospective validation set. Voxel-based lesion symptoms were assessed to identify voxels related to CMS, and a predictive model was constructed and tested in the validation and prospective validation sets. No significant differences were detected among these three data sets in CMS rate, gender, age, tumor size, tumor consistency, presence of hydrocephalus and paraventricular edema. Voxels related to CMS were mainly located in bilateral superior and inferior cerebellar peduncles and the superior part of the cerebellum. The areas under the curves for the model in the training, validation and prospective validation sets were 0.889, 0.784 and 0.791, respectively. Superior and inferior cerebellar peduncles and the superior part of the cerebellum were related to CMS, especially the right side, and voxel-based lesion-symptom analysis could provide valuable predictive information before surgery.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally as corresponding authors. These authors contributed equally as first authors.
ISSN:	2213-1582 2213-1582
DOI:	10.1016/j.nicl.2022.103291