Construction and Characterization of Virus-Like Particles: A Review

Over the last three decades, virus-like particles (VLPs) have evolved to become a widely accepted technology, especially in the field of vaccinology. In fact, some VLP-based vaccines are currently used as commercial medical products, and other VLP-based products are at different stages of clinical s...

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Vydáno v:Molecular biotechnology Ročník 53; číslo 1; s. 92 - 107
Hlavní autor: Zeltins, Andris
Médium: Journal Article
Jazyk:angličtina
Vydáno: New York Springer-Verlag 01.01.2013
Humana Press Inc
Springer Nature B.V
Témata:
Animals
Biochemistry
Biological Techniques
Biotechnology
Cell Biology
Cell-Free System
Cell-Free System - metabolism
Chemistry
Chemistry and Materials Science
Cloning
Cloning, Molecular
Data processing
Escherichia coli
Escherichia coli - genetics
Escherichia coli - metabolism
Gene therapy
Genes, Viral
Genetic Therapy
Genetic Vectors
genetics
Host systems
Human Genetics
Humans
immunology
Insecta
Insecta - genetics
Insecta - metabolism
Medical equipment
metabolism
Nanomaterials
Nanoparticles
Nanotechnology
Nucleic acids
Plants
Plants - genetics
Plants - metabolism
Protein Science
Purification
Recombinant Proteins
Recombinant Proteins - chemistry
Review
Reviews
Saccharomyces cerevisiae
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
structural genes
Structural integrity
Vaccines
Vaccines, Virus-Like Particle
Vaccines, Virus-Like Particle - chemistry
Vaccines, Virus-Like Particle - immunology
Viral Vaccines
Viral Vaccines - chemistry
Viral Vaccines - immunology
Virology
Virus-like particles
Viruses
Viruses - genetics
Viruses - immunology
Virus
Expression system
Self-assembly
Vaccine
Nanoparticle
Cloning
ISSN:1073-6085, 1559-0305, 1559-0305
On-line přístup:Získat plný text
Tagy: Přidat tag
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Abstract Over the last three decades, virus-like particles (VLPs) have evolved to become a widely accepted technology, especially in the field of vaccinology. In fact, some VLP-based vaccines are currently used as commercial medical products, and other VLP-based products are at different stages of clinical study. Several remarkable advantages have been achieved in the development of VLPs as gene therapy tools and new nanomaterials. The analysis of published data reveals that at least 110 VLPs have been constructed from viruses belonging to 35 different families. This review therefore discusses the main principles in the cloning of viral structural genes, the relevant host systems and the purification procedures that have been developed. In addition, the methods that are used to characterize the structural integrity, stability, and components, including the encapsidated nucleic acids, of newly synthesized VLPs are analyzed. Moreover, some of the modifications that are required to construct VLP-based carriers of viral origin with defined properties are discussed, and examples are provided.
AbstractList Over the last three decades, virus-like particles (VLPs) have evolved to become a widely accepted technology, especially in the field of vaccinology. In fact, some VLP-based vaccines are currently used as commercial medical products, and other VLP-based products are at different stages of clinical study. Several remarkable advantages have been achieved in the development of VLPs as gene therapy tools and new nanomaterials. The analysis of published data reveals that at least 110 VLPs have been constructed from viruses belonging to 35 different families. This review therefore discusses the main principles in the cloning of viral structural genes, the relevant host systems and the purification procedures that have been developed. In addition, the methods that are used to characterize the structural integrity, stability, and components, including the encapsidated nucleic acids, of newly synthesized VLPs are analyzed. Moreover, some of the modifications that are required to construct VLP-based carriers of viral origin with defined properties are discussed, and examples are provided.Over the last three decades, virus-like particles (VLPs) have evolved to become a widely accepted technology, especially in the field of vaccinology. In fact, some VLP-based vaccines are currently used as commercial medical products, and other VLP-based products are at different stages of clinical study. Several remarkable advantages have been achieved in the development of VLPs as gene therapy tools and new nanomaterials. The analysis of published data reveals that at least 110 VLPs have been constructed from viruses belonging to 35 different families. This review therefore discusses the main principles in the cloning of viral structural genes, the relevant host systems and the purification procedures that have been developed. In addition, the methods that are used to characterize the structural integrity, stability, and components, including the encapsidated nucleic acids, of newly synthesized VLPs are analyzed. Moreover, some of the modifications that are required to construct VLP-based carriers of viral origin with defined properties are discussed, and examples are provided.
Over the last three decades, virus-like particles (VLPs) have evolved to become a widely accepted technology, especially in the field of vaccinology. In fact, some VLP-based vaccines are currently used as commercial medical products, and other VLP-based products are at different stages of clinical study. Several remarkable advantages have been achieved in the development of VLPs as gene therapy tools and new nanomaterials. The analysis of published data reveals that at least 110 VLPs have been constructed from viruses belonging to 35 different families. This review therefore discusses the main principles in the cloning of viral structural genes, the relevant host systems and the purification procedures that have been developed. In addition, the methods that are used to characterize the structural integrity, stability, and components, including the encapsidated nucleic acids, of newly synthesized VLPs are analyzed. Moreover, some of the modifications that are required to construct VLP-based carriers of viral origin with defined properties are discussed, and examples are provided.
Author Zeltins, Andris
Author_xml – sequence: 1
  fullname: Zeltins, Andris
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23001867$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/S0014-5793(00)02061-5
10.1016/j.virol.2009.06.023
10.1073/pnas.2237038100
10.1016/j.tibtech.2005.07.011
10.1038/nbt0786-637
10.1099/0022-1317-75-5-1101
10.1016/j.biotechadv.2011.09.016
10.1016/j.biochi.2011.12.006
10.1128/JVI.75.13.6154-6165.2001
10.1016/j.jip.2011.05.004
10.1002/mabi.201000330
10.1016/j.jmb.2011.07.063
10.1016/j.virol.2009.08.023
10.1016/j.bbrc.2011.04.129
10.1016/j.jbiotec.2011.04.011
10.1016/0042-6822(90)90159-O
10.1586/erv.10.115
10.1006/viro.1995.1108
10.1073/pnas.96.24.13650
10.1038/296677a0
10.1371/journal.pone.0032510
10.1146/annurev.immunol.15.1.235
10.1038/nbt0197-52
10.1016/j.vaccine.2011.05.075
10.1111/j.1467-7652.2010.00507.x
10.1128/jvi.71.10.7207-7213.1997
10.1016/S0960-9822(06)00331-9
10.1073/pnas.0608869103
10.4049/jimmunol.172.3.1777
10.1159/000067922
10.1186/1423-0127-16-69
10.1016/j.vaccine.2005.07.098
10.1099/vir.0.021212-0
10.1371/journal.pone.0009784
10.1128/JVI.00027-07
10.1038/nrg1066
10.1002/btpr.744
10.1016/j.jbiotec.2005.11.013
10.1016/j.pep.2010.09.010
10.1007/978-3-540-69379-6_1
10.1016/j.vaccine.2010.04.025
10.1016/j.virusres.2011.02.006
10.1016/j.coviro.2011.12.004
10.1002/jps.22304
10.1074/jbc.M603313200
10.1039/c0sc00407c
10.1128/CMR.00027-09
10.1038/srep00005
10.1371/journal.pone.0018437
10.1038/298347a0
10.1007/s00726-009-0365-1
10.1128/jvi.64.7.3319-3330.1990
10.1016/j.jmb.2008.08.060
10.1021/nn202493w
10.1016/B978-0-12-381357-2.00001-3
10.3748/wjg.v12.i6.921
10.1016/j.copbio.2010.07.004
10.1016/S0168-1656(00)00369-2
10.1016/j.antiviral.2011.06.003
10.1038/nbt0706-769
10.1016/j.jbiotec.2007.12.004
10.1371/journal.pone.0000415
10.1002/cbic.201000094
10.1038/nm.2105
10.1007/s00705-009-0336-6
10.1073/pnas.1116168109
10.1006/viro.1995.1283
10.1038/279043a0
10.1021/bi901306p
10.1016/j.jbiotec.2005.01.010
10.1186/1743-422X-7-279
10.1128/aem.54.8.1983-1988.1988
10.1021/ac034848s
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10.1186/1743-422X-7-166
10.1038/nbt1026
10.1016/0042-6822(92)90676-G
10.1186/1743-422X-7-146
10.1006/jmbi.1997.1258
10.1007/s10529-007-9345-2
10.1128/jvi.67.5.2756-2763.1993
10.1016/j.virol.2009.02.051
10.1126/science.8248784
10.1073/pnas.1101874108
10.1038/nrd1284
10.1007/82_2011_158
10.1128/JVI.73.5.4239-4250.1999
10.1007/82_2011_184
10.1016/j.vaccine.2010.07.055
10.1016/j.biotechadv.2012.01.009
10.1006/viro.2001.1242
10.1039/b715299j
10.1038/nnano.2009.38
10.1073/pnas.91.19.9067
10.1016/j.biotechadv.2009.03.004
10.1080/03639040802192806
10.1099/vir.0.19688-0
10.1111/j.1742-4658.2005.05033.x
10.1128/JVI.00749-09
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10.1023/A:1025780611356
10.1002/j.1460-2075.1992.tb05156.x
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10.1099/0022-1317-77-7-1349
10.1021/ja907843s
10.1099/0022-1317-82-1-259
10.1093/nar/gkq901
10.1038/mt.2009.41
10.1128/jvi.70.8.5016-5024.1996
10.1128/JVI.78.23.13285-13292.2004
10.1111/j.1365-2567.2007.02676.x
10.1021/ja077801n
10.1021/bc100367u
10.1186/1475-2859-10-33
10.1128/jvi.71.10.8066-8072.1997
10.1098/rstb.2011.0103
10.1186/1475-2859-10-48
10.1016/j.jbiotec.2007.05.013
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Issue 1
Keywords Virus
Expression system
Self-assembly
Vaccine
Nanoparticle
Cloning
Language English
License This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
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PublicationSubtitle Part B of Applied Biochemistry and Biotechnology
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References MF Bachmann (9598_CR8) 2004; 3
T Kato (9598_CR51) 2012; S9
S Brumfield (9598_CR43) 2004; 85
M Cull (9598_CR80) 1990; 182
FM Wurm (9598_CR70) 2004; 22
P Fender (9598_CR154) 1997; 15
L Goodridge (9598_CR90) 2004; 76
E Rybicki (9598_CR62) 2010; 8
Y Gleba (9598_CR68) 2007; 18
NG Cortes-Perez (9598_CR35) 2009; 2
XS Chen (9598_CR31) 2000; 5
M Sastri (9598_CR149) 1997; 272
Y Seow (9598_CR11) 2009; 17
9598_CR75
HS Savithri (9598_CR100) 2010; 98
ML Smith (9598_CR124) 2006; 348
M Newman (9598_CR116) 2009; 83
K Sasnauskas (9598_CR158) 2002; 45
MH Tremblay (9598_CR137) 2006; 273
MF Bachmann (9598_CR6) 1997; 15
L Hou (9598_CR26) 2009; 154
T Vicente (9598_CR79) 2011; 29
P Plevka (9598_CR99) 2009; 391
G Spohn (9598_CR122) 2010; 7
I Cielens (9598_CR143) 2000; 482
S Werner (9598_CR130) 2006; 103
JL Mokili (9598_CR134) 2012; 2
T Storni (9598_CR114) 2004; 172
MT Smith (9598_CR76) 2012; 28
C Li (9598_CR150) 2010; 28
SP Sánchez-Rodríguez (9598_CR22) 2012; 94
TC Li (9598_CR142) 1997; 71
D Legendre (9598_CR37) 2005; 117
P Valenzuela (9598_CR18) 1982; 298
MA Krol (9598_CR42) 1999; 96
KJ Hofmann (9598_CR45) 1995; 209
K Saunders (9598_CR58) 2009; 393
LJ White (9598_CR87) 1997; 71
CJ Burrell (9598_CR17) 1979; 279
P Molinari (9598_CR60) 2008; 147
GD Lewis (9598_CR84) 1988; 54
B Wróbel (9598_CR86) 2000; 84
J Freivalds (9598_CR44) 2011; 75
KL Warfield (9598_CR151) 2003; 100
JT Saliki (9598_CR157) 1992; 73
E Kaltgrad (9598_CR118) 2008; 130
C Pastori (9598_CR123) 2012; 431
J Freivalds (9598_CR39) 2008; 745
N Ohtake (9598_CR128) 2010; 11
R Lang (9598_CR105) 2009; 35
ZA Janowicz (9598_CR47) 1991; 7
JS Park (9598_CR132) 2009; 4
CY Wu (9598_CR72) 2010; 5
JE Voss (9598_CR94) 2010; 468
F Powilleit (9598_CR41) 2007; 2
T Latham (9598_CR56) 2001; 75
JD Tatman (9598_CR54) 1994; 75
J Rumnieks (9598_CR104) 2009; 391
A Fernández-Arias (9598_CR153) 1998; 79
D Cardinale (9598_CR133) 2012; 30
LK Pattenden (9598_CR14) 2005; 23
KG Patel (9598_CR78) 2011; 22
A Natilla (9598_CR125) 2011; 178
SW Metz (9598_CR57) 2011; 6
F Liu (9598_CR4) 2012; 93
A Rogel (9598_CR29) 2003; 27
P Saccardo (9598_CR16) 2009; 27
RW Hammond (9598_CR30) 2010; 147
BJ Cohen (9598_CR20) 1982; 296
WW Newcomb (9598_CR156) 1999; 73
C Bragard (9598_CR107) 2000; 81
S Gleiter (9598_CR131) 2005; 384
SF Ausar (9598_CR102) 2006; 281
YP Chuan (9598_CR21) 2008; 20
LA Lee (9598_CR13) 2009; 2
A Brun (9598_CR7) 2011; 157
SD Fuller (9598_CR92) 1997; 7
CM Soto (9598_CR12) 2010; 21
WA Rodríguez-Limas (9598_CR48) 2011; 10
P Pushko (9598_CR55) 2005; 23
CO Tacket (9598_CR65) 2009; 332
F Birnbaum (9598_CR85) 1990; 64
H Ju (9598_CR34) 2011; 409
ME Janssens (9598_CR135) 2010; 38
L Yao (9598_CR61) 2012; 7
RA Crowther (9598_CR96) 2010; 81
M Persson (9598_CR98) 2008; 383
G Spohn (9598_CR120) 2007; 178
9598_CR27
I Mena (9598_CR73) 1996; 70
S Caballero (9598_CR138) 2004; 78
J Freivalds (9598_CR38) 2006; 123
CE Thomas (9598_CR113) 2003; 4
N Ohtaki (9598_CR141) 2010; 28
CS Goldsmith (9598_CR97) 2009; 22
A Roldão (9598_CR5) 2010; 9
Q Zhao (9598_CR83) 2012; 9
GL Lokesh (9598_CR108) 2002; 292
S Kumar (9598_CR95) 2009; 388
G Walsh (9598_CR71) 2006; 24
JW Lamb (9598_CR144) 1996; 77
W Akahata (9598_CR74) 2010; 16
LM Branco (9598_CR88) 2010; 7
AP Middelberg (9598_CR32) 2011; 29
A Schneemann (9598_CR145) 1993; 67
M Juozapaitis (9598_CR46) 2007; 130
IJ Minten (9598_CR126) 2011; 2
M Hema (9598_CR109) 2008; 46
A Zeltins (9598_CR63) 2009
MF Bachmann (9598_CR121) 2011; 366
J Kissmann (9598_CR106) 2011; 100
B Lamarre (9598_CR10) 2011; 8
O Salazar (9598_CR81) 2007; 29
S Yin (9598_CR155) 2010; 7
MA Gomez-Lim (9598_CR66) 2009
SD Brown (9598_CR28) 2009; 48
T Hoenen (9598_CR15) 2011; 91
Y Morikawa (9598_CR49) 2007; 81
EA Hewat (9598_CR91) 1992; 189
FM Pringle (9598_CR148) 2001; 82
H Lünsdorf (9598_CR50) 2011; 10
XY Lu (9598_CR140) 2007; 122
H Lai (9598_CR64) 2012; 31
SW Lane (9598_CR101) 2011; 413
CY Fang (9598_CR117) 2012; 182
JP Phelps (9598_CR36) 2007; 128
A Walker (9598_CR129) 2011; 1
HS Mason (9598_CR67) 2012; 354
M Shanks (9598_CR147) 2000; 81
MF Bachmann (9598_CR9) 1993; 262
NR Burns (9598_CR40) 1992; 11
E Hardy (9598_CR82) 2000; 77
IH Frazer (9598_CR3) 2004; 4
DH Bunka (9598_CR111) 2011; 413
CD Lee (9598_CR33) 2009; 16
O Farnós (9598_CR139) 2009; 81
JZ Porterfield (9598_CR89) 2010; 407
BC Bundy (9598_CR77) 2011; 154
P Pumpens (9598_CR1) 2002
L Luo (9598_CR146) 1990; 179
JL Cuellar (9598_CR103) 2010; 91
Y Xu (9598_CR24) 2008; 1
C Hulo (9598_CR136) 2011; 39
BC Ng (9598_CR115) 2011; 5
SJ Kaczmarczyk (9598_CR112) 2011; 108
E Strable (9598_CR119) 2009; 327
JR Haynes (9598_CR19) 1986; 4
S Sokolenko (9598_CR53) 2012; 30
P Pumpens (9598_CR2) 2009
DJ Hwang (9598_CR25) 1994; 91
9598_CR69
IJ Minten (9598_CR127) 2009; 131
T Vicente (9598_CR52) 2011; 107
YC Chung (9598_CR59) 2006; 12
X Yu (9598_CR93) 2007; 367
A Routh (9598_CR110) 2012; 109
X Zhao (9598_CR23) 1995; 10
P Walpita (9598_CR152) 2011; 6
References_xml – volume: 482
  start-page: 261
  year: 2000
  ident: 9598_CR143
  publication-title: FEBS Letters
  doi: 10.1016/S0014-5793(00)02061-5
– volume: 391
  start-page: 187
  year: 2009
  ident: 9598_CR104
  publication-title: Virology
  doi: 10.1016/j.virol.2009.06.023
– volume: 100
  start-page: 15889
  year: 2003
  ident: 9598_CR151
  publication-title: Proceedings of the National Academy of Science of the United States of America
  doi: 10.1073/pnas.2237038100
– volume: 23
  start-page: 523
  year: 2005
  ident: 9598_CR14
  publication-title: Trends in Biotechnology
  doi: 10.1016/j.tibtech.2005.07.011
– volume: 4
  start-page: 637
  year: 1986
  ident: 9598_CR19
  publication-title: Biotechnology
  doi: 10.1038/nbt0786-637
– volume: 75
  start-page: 1101
  issue: Pt 5
  year: 1994
  ident: 9598_CR54
  publication-title: Journal of General Virology
  doi: 10.1099/0022-1317-75-5-1101
– ident: 9598_CR75
  doi: 10.1016/j.biotechadv.2011.09.016
– volume: 94
  start-page: 870
  year: 2012
  ident: 9598_CR22
  publication-title: Biochimie
  doi: 10.1016/j.biochi.2011.12.006
– volume: 75
  start-page: 6154
  year: 2001
  ident: 9598_CR56
  publication-title: Journal of Virology
  doi: 10.1128/JVI.75.13.6154-6165.2001
– volume: 107
  start-page: S42
  year: 2011
  ident: 9598_CR52
  publication-title: Journal of Invertebrate Pathology
  doi: 10.1016/j.jip.2011.05.004
– volume: 8
  start-page: 503
  year: 2011
  ident: 9598_CR10
  publication-title: Macromolecular Bioscience
  doi: 10.1002/mabi.201000330
– volume: 413
  start-page: 51
  year: 2011
  ident: 9598_CR111
  publication-title: Journal of Molecular Biology
  doi: 10.1016/j.jmb.2011.07.063
– volume: 393
  start-page: 329
  year: 2009
  ident: 9598_CR58
  publication-title: Virology
  doi: 10.1016/j.virol.2009.08.023
– volume: 384
  start-page: 247
  year: 2005
  ident: 9598_CR131
  publication-title: Biological Chemistry
– volume: 409
  start-page: 131
  year: 2011
  ident: 9598_CR34
  publication-title: Biochemical and Biophysical Research Communications
  doi: 10.1016/j.bbrc.2011.04.129
– volume: 154
  start-page: 230
  year: 2011
  ident: 9598_CR77
  publication-title: Journal of Biotechnology
  doi: 10.1016/j.jbiotec.2011.04.011
– volume: 179
  start-page: 874
  year: 1990
  ident: 9598_CR146
  publication-title: Virology
  doi: 10.1016/0042-6822(90)90159-O
– volume: 9
  start-page: 1149
  year: 2010
  ident: 9598_CR5
  publication-title: Expert Review of Vaccines
  doi: 10.1586/erv.10.115
– volume: 10
  start-page: 486
  year: 1995
  ident: 9598_CR23
  publication-title: Virology
  doi: 10.1006/viro.1995.1108
– volume: 96
  start-page: 13650
  year: 1999
  ident: 9598_CR42
  publication-title: Proceedings of the National Academy of Science of the United States of America
  doi: 10.1073/pnas.96.24.13650
– volume: 296
  start-page: 677
  year: 1982
  ident: 9598_CR20
  publication-title: Nature
  doi: 10.1038/296677a0
– volume: 7
  start-page: e32510
  issue: 3
  year: 2012
  ident: 9598_CR61
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0032510
– volume: 15
  start-page: 235
  year: 1997
  ident: 9598_CR6
  publication-title: Annual Review of Immunology
  doi: 10.1146/annurev.immunol.15.1.235
– volume: 15
  start-page: 52
  year: 1997
  ident: 9598_CR154
  publication-title: Nature Biotechnology
  doi: 10.1038/nbt0197-52
– volume: 29
  start-page: 7154
  year: 2011
  ident: 9598_CR32
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2011.05.075
– volume: 8
  start-page: 620
  year: 2010
  ident: 9598_CR62
  publication-title: Plant Biotechnology Journal
  doi: 10.1111/j.1467-7652.2010.00507.x
– volume: 71
  start-page: 7207
  year: 1997
  ident: 9598_CR142
  publication-title: Journal of Virology
  doi: 10.1128/jvi.71.10.7207-7213.1997
– volume: 7
  start-page: 729
  year: 1997
  ident: 9598_CR92
  publication-title: Current Biology
  doi: 10.1016/S0960-9822(06)00331-9
– volume: 98
  start-page: 346
  year: 2010
  ident: 9598_CR100
  publication-title: Current Science
– volume: 103
  start-page: 17678
  year: 2006
  ident: 9598_CR130
  publication-title: Proceedings of the National Academy of Science of the United States of America
  doi: 10.1073/pnas.0608869103
– volume: 172
  start-page: 1777
  year: 2004
  ident: 9598_CR114
  publication-title: Journal of Immunology
  doi: 10.4049/jimmunol.172.3.1777
– volume: 45
  start-page: 308
  year: 2002
  ident: 9598_CR158
  publication-title: Intervirology
  doi: 10.1159/000067922
– volume: 16
  start-page: 69
  year: 2009
  ident: 9598_CR33
  publication-title: Journal of Biomedical Science
  doi: 10.1186/1423-0127-16-69
– volume: 23
  start-page: 5751
  year: 2005
  ident: 9598_CR55
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2005.07.098
– volume: 91
  start-page: 2449
  year: 2010
  ident: 9598_CR103
  publication-title: Journal of General Virology
  doi: 10.1099/vir.0.021212-0
– volume: 5
  start-page: e9784
  issue: 3
  year: 2010
  ident: 9598_CR72
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0009784
– volume: 81
  start-page: 9911
  year: 2007
  ident: 9598_CR49
  publication-title: Journal of Virology
  doi: 10.1128/JVI.00027-07
– volume: 4
  start-page: 346
  year: 2003
  ident: 9598_CR113
  publication-title: Nature Reviews Genetics
  doi: 10.1038/nrg1066
– volume: 28
  start-page: 549
  year: 2012
  ident: 9598_CR76
  publication-title: Biotechnology Progress
  doi: 10.1002/btpr.744
– volume: 123
  start-page: 297
  year: 2006
  ident: 9598_CR38
  publication-title: Journal of Biotechnology
  doi: 10.1016/j.jbiotec.2005.11.013
– start-page: 249
  volume-title: Artificial DNA: Methods and applications
  year: 2002
  ident: 9598_CR1
– volume: 75
  start-page: 218
  year: 2011
  ident: 9598_CR44
  publication-title: Protein Expression and Purification
  doi: 10.1016/j.pep.2010.09.010
– volume: 327
  start-page: 1
  year: 2009
  ident: 9598_CR119
  publication-title: Current Topics in Microbiology and Immunology
  doi: 10.1007/978-3-540-69379-6_1
– volume: 28
  start-page: 4294
  year: 2010
  ident: 9598_CR150
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2010.04.025
– volume: 157
  start-page: 1
  year: 2011
  ident: 9598_CR7
  publication-title: Virus Research
  doi: 10.1016/j.virusres.2011.02.006
– volume: 2
  start-page: 63
  year: 2012
  ident: 9598_CR134
  publication-title: Current Opinion in Virology
  doi: 10.1016/j.coviro.2011.12.004
– volume: 100
  start-page: 634
  year: 2011
  ident: 9598_CR106
  publication-title: Journal of Pharmaceutical Sciences
  doi: 10.1002/jps.22304
– volume: 281
  start-page: 19478
  year: 2006
  ident: 9598_CR102
  publication-title: Journal of Biological Chemistry
  doi: 10.1074/jbc.M603313200
– volume: 2
  start-page: 358
  year: 2011
  ident: 9598_CR126
  publication-title: Chemical Science
  doi: 10.1039/c0sc00407c
– volume: 22
  start-page: 552
  year: 2009
  ident: 9598_CR97
  publication-title: Clinical Microbiology Reviews
  doi: 10.1128/CMR.00027-09
– volume: 1
  start-page: 5
  year: 2011
  ident: 9598_CR129
  publication-title: Scientific Reports
  doi: 10.1038/srep00005
– volume: 6
  start-page: e18437
  issue: 4
  year: 2011
  ident: 9598_CR152
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0018437
– volume: 298
  start-page: 347
  year: 1982
  ident: 9598_CR18
  publication-title: Nature
  doi: 10.1038/298347a0
– volume: 38
  start-page: 1617
  year: 2010
  ident: 9598_CR135
  publication-title: Amino Acids
  doi: 10.1007/s00726-009-0365-1
– volume: 64
  start-page: 3319
  year: 1990
  ident: 9598_CR85
  publication-title: Journal of Virology
  doi: 10.1128/jvi.64.7.3319-3330.1990
– volume: 383
  start-page: 914
  year: 2008
  ident: 9598_CR98
  publication-title: Journal of Molecular Biology
  doi: 10.1016/j.jmb.2008.08.060
– volume: 5
  start-page: 7730
  year: 2011
  ident: 9598_CR115
  publication-title: ACS Nano
  doi: 10.1021/nn202493w
– volume: 81
  start-page: 1
  year: 2010
  ident: 9598_CR96
  publication-title: Advances in Protein Chemistry and Structural Biology
  doi: 10.1016/B978-0-12-381357-2.00001-3
– volume: 12
  start-page: 921
  year: 2006
  ident: 9598_CR59
  publication-title: World Journal of Gastroenterology
  doi: 10.3748/wjg.v12.i6.921
– volume: 21
  start-page: 426
  year: 2010
  ident: 9598_CR12
  publication-title: Current Opinion in Biotechnology
  doi: 10.1016/j.copbio.2010.07.004
– volume: 84
  start-page: 285
  year: 2000
  ident: 9598_CR86
  publication-title: Journal of Biotechnology
  doi: 10.1016/S0168-1656(00)00369-2
– volume: 91
  start-page: 195
  year: 2011
  ident: 9598_CR15
  publication-title: Antiviral Research
  doi: 10.1016/j.antiviral.2011.06.003
– volume: 24
  start-page: 769
  year: 2006
  ident: 9598_CR71
  publication-title: Nature Biotechnology
  doi: 10.1038/nbt0706-769
– volume: 20
  start-page: 64
  year: 2008
  ident: 9598_CR21
  publication-title: Journal of Biotechnology
  doi: 10.1016/j.jbiotec.2007.12.004
– volume: 2
  start-page: e415
  issue: 5
  year: 2007
  ident: 9598_CR41
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0000415
– volume: 11
  start-page: 959
  year: 2010
  ident: 9598_CR128
  publication-title: ChemBioChem
  doi: 10.1002/cbic.201000094
– volume: 16
  start-page: 334
  year: 2010
  ident: 9598_CR74
  publication-title: Nature Medicine
  doi: 10.1038/nm.2105
– volume: 154
  start-page: 547
  year: 2009
  ident: 9598_CR26
  publication-title: Archives of Virology
  doi: 10.1007/s00705-009-0336-6
– volume: 109
  start-page: 1907
  year: 2012
  ident: 9598_CR110
  publication-title: Proceedings of the National Academy of Science of the United States of America
  doi: 10.1073/pnas.1116168109
– volume: 209
  start-page: 506
  year: 1995
  ident: 9598_CR45
  publication-title: Virology
  doi: 10.1006/viro.1995.1283
– volume: 279
  start-page: 43
  year: 1979
  ident: 9598_CR17
  publication-title: Nature
  doi: 10.1038/279043a0
– volume: 48
  start-page: 11155
  year: 2009
  ident: 9598_CR28
  publication-title: Biochemistry
  doi: 10.1021/bi901306p
– volume: 117
  start-page: 183
  year: 2005
  ident: 9598_CR37
  publication-title: Journal of Biotechnology
  doi: 10.1016/j.jbiotec.2005.01.010
– volume: 7
  start-page: 279
  year: 2010
  ident: 9598_CR88
  publication-title: Virology Journal
  doi: 10.1186/1743-422X-7-279
– volume: 54
  start-page: 1983
  year: 1988
  ident: 9598_CR84
  publication-title: Applied and Environmental Microbiology
  doi: 10.1128/aem.54.8.1983-1988.1988
– volume: 76
  start-page: 48
  year: 2004
  ident: 9598_CR90
  publication-title: Analytical Chemistry
  doi: 10.1021/ac034848s
– volume: 431
  start-page: 1
  year: 2012
  ident: 9598_CR123
  publication-title: Virology
  doi: 10.1016/j.virol.2012.05.005
– volume: 7
  start-page: 166
  year: 2010
  ident: 9598_CR155
  publication-title: Virology Journal
  doi: 10.1186/1743-422X-7-166
– volume: 22
  start-page: 1393
  year: 2004
  ident: 9598_CR70
  publication-title: Nature Biotechnology
  doi: 10.1038/nbt1026
– volume: 189
  start-page: 10
  year: 1992
  ident: 9598_CR91
  publication-title: Virology
  doi: 10.1016/0042-6822(92)90676-G
– volume: 7
  start-page: 146
  year: 2010
  ident: 9598_CR122
  publication-title: Virology Journal
  doi: 10.1186/1743-422X-7-146
– volume: 272
  start-page: 541
  year: 1997
  ident: 9598_CR149
  publication-title: Journal of Molecular Biology
  doi: 10.1006/jmbi.1997.1258
– volume: 29
  start-page: 985
  year: 2007
  ident: 9598_CR81
  publication-title: Biotechnology Letters
  doi: 10.1007/s10529-007-9345-2
– volume: 67
  start-page: 2756
  year: 1993
  ident: 9598_CR145
  publication-title: Journal of Virology
  doi: 10.1128/jvi.67.5.2756-2763.1993
– start-page: 445
  volume-title: Medicinal protein engineering
  year: 2009
  ident: 9598_CR66
– volume: 388
  start-page: 185
  year: 2009
  ident: 9598_CR95
  publication-title: Virology
  doi: 10.1016/j.virol.2009.02.051
– volume: 262
  start-page: 1448
  year: 1993
  ident: 9598_CR9
  publication-title: Science
  doi: 10.1126/science.8248784
– volume: 108
  start-page: 16998
  year: 2011
  ident: 9598_CR112
  publication-title: Proceedings of the National Academy of Science of the United States of America
  doi: 10.1073/pnas.1101874108
– volume: 3
  start-page: 81
  year: 2004
  ident: 9598_CR8
  publication-title: Nature Reviews Drug Discovery
  doi: 10.1038/nrd1284
– volume: 354
  start-page: 101
  year: 2012
  ident: 9598_CR67
  publication-title: Current Topics in Microbiology and Immunology
  doi: 10.1007/82_2011_158
– volume: 73
  start-page: 4239
  year: 1999
  ident: 9598_CR156
  publication-title: Journal of Virology
  doi: 10.1128/JVI.73.5.4239-4250.1999
– ident: 9598_CR69
  doi: 10.1007/82_2011_184
– volume: 28
  start-page: 6588
  year: 2010
  ident: 9598_CR141
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2010.07.055
– volume: 30
  start-page: 766
  year: 2012
  ident: 9598_CR53
  publication-title: Biotechnology Advances
  doi: 10.1016/j.biotechadv.2012.01.009
– volume: 292
  start-page: 211
  year: 2002
  ident: 9598_CR108
  publication-title: Virology
  doi: 10.1006/viro.2001.1242
– volume: 1
  start-page: 49
  year: 2008
  ident: 9598_CR24
  publication-title: Chemical Communications
  doi: 10.1039/b715299j
– volume: 4
  start-page: 259
  year: 2009
  ident: 9598_CR132
  publication-title: Nature Nanotechnology
  doi: 10.1038/nnano.2009.38
– volume: 91
  start-page: 9067
  year: 1994
  ident: 9598_CR25
  publication-title: Proceedings of the National Academy of Science of the United States of America
  doi: 10.1073/pnas.91.19.9067
– volume: 27
  start-page: 432
  year: 2009
  ident: 9598_CR16
  publication-title: Biotechnology Advances
  doi: 10.1016/j.biotechadv.2009.03.004
– volume: 35
  start-page: 83
  year: 2009
  ident: 9598_CR105
  publication-title: Drug Development and Industrial Pharmacy
  doi: 10.1080/03639040802192806
– volume: 85
  start-page: 1049
  year: 2004
  ident: 9598_CR43
  publication-title: Journal of General Virology
  doi: 10.1099/vir.0.19688-0
– volume: S9
  start-page: 001
  year: 2012
  ident: 9598_CR51
  publication-title: Journal of Biotechnology & Biomaterials
– volume: 273
  start-page: 14
  year: 2006
  ident: 9598_CR137
  publication-title: FEBS Journal
  doi: 10.1111/j.1742-4658.2005.05033.x
– start-page: 481
  volume-title: Medicinal protein engineering
  year: 2009
  ident: 9598_CR63
– volume: 83
  start-page: 10616
  year: 2009
  ident: 9598_CR116
  publication-title: Journal of Virology
  doi: 10.1128/JVI.00749-09
– volume: 93
  start-page: 553
  year: 2012
  ident: 9598_CR4
  publication-title: Research in Veterinary Science
  doi: 10.1016/j.rvsc.2011.10.018
– volume: 4
  start-page: 46
  year: 2004
  ident: 9598_CR3
  publication-title: Nature Reviews Immunology
  doi: 10.1038/nri1260
– volume: 468
  start-page: 709
  year: 2010
  ident: 9598_CR94
  publication-title: Nature
  doi: 10.1038/nature09555
– volume: 31
  start-page: 573
  issue: 3
  year: 2012
  ident: 9598_CR64
  publication-title: Plant Cell Reports
  doi: 10.1007/s00299-011-1196-6
– volume: 77
  start-page: 157
  year: 2000
  ident: 9598_CR82
  publication-title: Journal of Biotechnology
  doi: 10.1016/S0168-1656(99)00201-1
– volume: 30
  start-page: 369
  year: 2012
  ident: 9598_CR133
  publication-title: Trends in Biotechnology
  doi: 10.1016/j.tibtech.2012.04.001
– volume: 79
  start-page: 1047
  year: 1998
  ident: 9598_CR153
  publication-title: Journal of General Virology
  doi: 10.1099/0022-1317-79-5-1047
– volume: 73
  start-page: 369
  year: 1992
  ident: 9598_CR157
  publication-title: Journal of General Virology
  doi: 10.1099/0022-1317-73-2-369
– volume: 9
  start-page: 52
  year: 2012
  ident: 9598_CR83
  publication-title: Virology Journal
  doi: 10.1186/1743-422X-9-52
– volume: 18
  start-page: 134
  year: 2007
  ident: 9598_CR68
  publication-title: Current Opinion in Biotechnology
  doi: 10.1016/j.copbio.2007.03.002
– volume: 81
  start-page: 3093
  year: 2000
  ident: 9598_CR147
  publication-title: Journal of General Virology
  doi: 10.1099/0022-1317-81-12-3093
– volume: 178
  start-page: 209
  year: 2011
  ident: 9598_CR125
  publication-title: Journal of Virological Methods
  doi: 10.1016/j.jviromet.2011.09.013
– volume: 128
  start-page: 290
  year: 2007
  ident: 9598_CR36
  publication-title: Journal of Biotechnology
  doi: 10.1016/j.jbiotec.2006.10.005
– volume: 407
  start-page: 281
  year: 2010
  ident: 9598_CR89
  publication-title: Virology
  doi: 10.1016/j.virol.2010.08.015
– volume: 745
  start-page: 75
  year: 2008
  ident: 9598_CR39
  publication-title: Acta Universitatis Latviensis
– volume: 348
  start-page: 475
  year: 2006
  ident: 9598_CR124
  publication-title: Virology
  doi: 10.1016/j.virol.2005.12.039
– volume: 367
  start-page: 126
  year: 2007
  ident: 9598_CR93
  publication-title: Virology
  doi: 10.1016/j.virol.2007.05.038
– volume: 391
  start-page: 635
  year: 2009
  ident: 9598_CR99
  publication-title: Journal of Molecular Biology
  doi: 10.1016/j.jmb.2009.06.047
– volume: 81
  start-page: 25
  year: 2009
  ident: 9598_CR139
  publication-title: Antiviral Research
  doi: 10.1016/j.antiviral.2008.08.007
– volume: 2
  start-page: 349
  year: 2009
  ident: 9598_CR13
  publication-title: Nano Research
  doi: 10.1007/s12274-009-9033-8
– volume: 6
  start-page: e25816
  issue: 10
  year: 2011
  ident: 9598_CR57
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0025816
– volume: 182
  start-page: 87
  year: 2012
  ident: 9598_CR117
  publication-title: Journal of Virological Methods
  doi: 10.1016/j.jviromet.2012.03.017
– volume: 27
  start-page: 169
  year: 2003
  ident: 9598_CR29
  publication-title: Virus Genes
  doi: 10.1023/A:1025780611356
– volume: 11
  start-page: 1155
  year: 1992
  ident: 9598_CR40
  publication-title: EMBO Journal
  doi: 10.1002/j.1460-2075.1992.tb05156.x
– volume: 147
  start-page: 208
  year: 2010
  ident: 9598_CR30
  publication-title: Virus Research
  doi: 10.1016/j.virusres.2009.11.002
– volume: 178
  start-page: 7450
  year: 2007
  ident: 9598_CR120
  publication-title: Journal of Immunology
  doi: 10.4049/jimmunol.178.11.7450
– volume: 2
  start-page: 167
  year: 2009
  ident: 9598_CR35
  publication-title: BMC Research Notes
  doi: 10.1186/1756-0500-2-167
– start-page: 205
  volume-title: Medicinal protein engineering
  year: 2009
  ident: 9598_CR2
– ident: 9598_CR27
  doi: 10.1007/s12033-011-9480-9
– volume: 147
  start-page: 364
  year: 2008
  ident: 9598_CR60
  publication-title: Journal of Virological Methods
  doi: 10.1016/j.jviromet.2007.09.002
– volume: 5
  start-page: 557
  year: 2000
  ident: 9598_CR31
  publication-title: Molecular Cell
  doi: 10.1016/S1097-2765(00)80449-9
– volume: 332
  start-page: 103
  year: 2009
  ident: 9598_CR65
  publication-title: Current Topics in Microbiology and Immunology
  doi: 10.1007/978-3-540-70868-1_6
– volume: 413
  start-page: 41
  year: 2011
  ident: 9598_CR101
  publication-title: Journal of Molecular Biology
  doi: 10.1016/j.jmb.2011.07.062
– volume: 7
  start-page: 431
  year: 1991
  ident: 9598_CR47
  publication-title: Yeast
  doi: 10.1002/yea.320070502
– volume: 77
  start-page: 1349
  year: 1996
  ident: 9598_CR144
  publication-title: Journal of General Virology
  doi: 10.1099/0022-1317-77-7-1349
– volume: 131
  start-page: 17771
  year: 2009
  ident: 9598_CR127
  publication-title: Journal of the American Chemical Society
  doi: 10.1021/ja907843s
– volume: 82
  start-page: 259
  year: 2001
  ident: 9598_CR148
  publication-title: Journal of General Virology
  doi: 10.1099/0022-1317-82-1-259
– volume: 39
  start-page: D576
  year: 2011
  ident: 9598_CR136
  publication-title: Nucleic Acids Research
  doi: 10.1093/nar/gkq901
– volume: 17
  start-page: 767
  year: 2009
  ident: 9598_CR11
  publication-title: Molecular Therapy
  doi: 10.1038/mt.2009.41
– volume: 70
  start-page: 5016
  year: 1996
  ident: 9598_CR73
  publication-title: Journal of Virology
  doi: 10.1128/jvi.70.8.5016-5024.1996
– volume: 78
  start-page: 13285
  year: 2004
  ident: 9598_CR138
  publication-title: Journal of Virology
  doi: 10.1128/JVI.78.23.13285-13292.2004
– volume: 122
  start-page: 496
  year: 2007
  ident: 9598_CR140
  publication-title: Immunology
  doi: 10.1111/j.1365-2567.2007.02676.x
– volume: 81
  start-page: 267
  year: 2000
  ident: 9598_CR107
  publication-title: Journal of General Virology
– volume: 130
  start-page: 4578
  year: 2008
  ident: 9598_CR118
  publication-title: Journal of the American Chemical Society
  doi: 10.1021/ja077801n
– volume: 22
  start-page: 376
  year: 2011
  ident: 9598_CR78
  publication-title: Bioconjugate Chemistry
  doi: 10.1021/bc100367u
– volume: 10
  start-page: 33
  year: 2011
  ident: 9598_CR48
  publication-title: Microbial Cell Factories
  doi: 10.1186/1475-2859-10-33
– volume: 71
  start-page: 8066
  year: 1997
  ident: 9598_CR87
  publication-title: Journal of Virology
  doi: 10.1128/jvi.71.10.8066-8072.1997
– volume: 366
  start-page: 2815
  year: 2011
  ident: 9598_CR121
  publication-title: Philosophical Transactions of the Royal Society B: Biological Sciences
  doi: 10.1098/rstb.2011.0103
– volume: 10
  start-page: 48
  year: 2011
  ident: 9598_CR50
  publication-title: Microbial Cell Factories
  doi: 10.1186/1475-2859-10-48
– volume: 130
  start-page: 441
  year: 2007
  ident: 9598_CR46
  publication-title: Journal of Biotechnology
  doi: 10.1016/j.jbiotec.2007.05.013
– volume: 182
  start-page: 147
  year: 1990
  ident: 9598_CR80
  publication-title: Methods in Enzymology
  doi: 10.1016/0076-6879(90)82014-S
– volume: 46
  start-page: 793
  year: 2008
  ident: 9598_CR109
  publication-title: Indian Journal of Experimental Biology
– volume: 29
  start-page: 869
  year: 2011
  ident: 9598_CR79
  publication-title: Biotechnology Advances
  doi: 10.1016/j.biotechadv.2011.07.004
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Biochemistry
Biological Techniques
Biotechnology
Cell Biology
Cell-Free System
Cell-Free System - metabolism
Chemistry
Chemistry and Materials Science
Cloning
Cloning, Molecular
Data processing
Escherichia coli
Escherichia coli - genetics
Escherichia coli - metabolism
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Genetic Vectors
genetics
Host systems
Human Genetics
Humans
immunology
Insecta
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Insecta - metabolism
Medical equipment
metabolism
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Nanoparticles
Nanotechnology
Nucleic acids
Plants
Plants - genetics
Plants - metabolism
Protein Science
Purification
Recombinant Proteins
Recombinant Proteins - chemistry
Review
Reviews
Saccharomyces cerevisiae
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
structural genes
Structural integrity
Vaccines
Vaccines, Virus-Like Particle
Vaccines, Virus-Like Particle - chemistry
Vaccines, Virus-Like Particle - immunology
Viral Vaccines
Viral Vaccines - chemistry
Viral Vaccines - immunology
Virology
Virus-like particles
Viruses
Viruses - genetics
Viruses - immunology
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