Emerging roles for neogenin and its ligands in CNS development

It is now well established that the netrin guidance cues and their receptors comprise a major molecular guidance system driving axon pathfinding during nervous system development. One netrin receptor, neogenin, is now emerging as a key regulator of many developmental processes throughout the embryo....

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Vydané v:	Journal of neurochemistry Ročník 106; číslo 4; s. 1483 - 1492
Hlavní autori:	De Vries, Melissa, Cooper, Helen M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.08.2008 Blackwell Publishing Ltd Blackwell
Predmet:	Amino Acid Sequence Animals axon guidance Biochemistry Biological and medical sciences Cell adhesion & migration Cell receptors Cell structures and functions Cellular biology Central Nervous System - cytology Central Nervous System - embryology Central Nervous System - physiology CNS development Development. Senescence. Regeneration. Transplantation Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental - physiology Humans Ligands Membrane Proteins - chemistry Membrane Proteins - metabolism Membrane Proteins - physiology Molecular and cellular biology Molecular biology Molecular Sequence Data Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) neogenin netrin Neurology repulsive guidance molecule Signal transduction signaling pathways Vertebrates: nervous system and sense organs netrin Embryo Interaction neogenin Central nervous system Nervous system Activation CNS development repulsive guidance molecule Epithelium Adhesion Guidance Signal transduction signaling pathways Development Differentiation axon guidance Biological receptor
ISSN:	0022-3042, 1471-4159, 1471-4159
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Popis
Shrnutí:	It is now well established that the netrin guidance cues and their receptors comprise a major molecular guidance system driving axon pathfinding during nervous system development. One netrin receptor, neogenin, is now emerging as a key regulator of many developmental processes throughout the embryo. Unexpectedly, a new family of neogenin ligands, the repulsive guidance molecule (RGM) family, has recently been identified. The functional outcome of neogenin activation is dictated by both the nature of the ligand as well as the developmental context. Netrin-1-neogenin interactions mediate chemoattractive axon guidance, while RGMa-neogenin interactions repel axons. Neogenin is required for the establishment of the pseudostratified epithelium of the neural tube, probably by promoting cell adhesion. In addition, a role for RGMa and neogenin in neuronal differentiation has been demonstrated. While neogenin signaling cascades are poorly understood, the opposing responses of neogenin to RGMa and netrin-1 in the context of axon guidance indicates that neogenin signaling is complex and subject to tight spatiotemporal regulation. In summary, neogenin is a multifunctional receptor regulating diverse developmental processes. Thus, its contribution to neural development is proving to be considerably more extensive than originally predicted.
Bibliografia:	http://dx.doi.org/10.1111/j.1471-4159.2008.05485.x ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Literature Review-2 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 ObjectType-Feature-2 ObjectType-Review-3
ISSN:	0022-3042 1471-4159 1471-4159
DOI:	10.1111/j.1471-4159.2008.05485.x