Emerging roles for neogenin and its ligands in CNS development

It is now well established that the netrin guidance cues and their receptors comprise a major molecular guidance system driving axon pathfinding during nervous system development. One netrin receptor, neogenin, is now emerging as a key regulator of many developmental processes throughout the embryo....

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Bibliographic Details
Published in:Journal of neurochemistry Vol. 106; no. 4; pp. 1483 - 1492
Main Authors: De Vries, Melissa, Cooper, Helen M
Format: Journal Article
Language:English
Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.08.2008
Blackwell Publishing Ltd
Blackwell
Subjects:
Amino Acid Sequence
Animals
axon guidance
Biochemistry
Biological and medical sciences
Cell adhesion & migration
Cell receptors
Cell structures and functions
Cellular biology
Central Nervous System - cytology
Central Nervous System - embryology
Central Nervous System - physiology
CNS development
Development. Senescence. Regeneration. Transplantation
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Developmental - physiology
Humans
Ligands
Membrane Proteins - chemistry
Membrane Proteins - metabolism
Membrane Proteins - physiology
Molecular and cellular biology
Molecular biology
Molecular Sequence Data
Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine)
neogenin
netrin
Neurology
repulsive guidance molecule
Signal transduction
signaling pathways
Vertebrates: nervous system and sense organs
netrin
Embryo
Interaction
neogenin
Central nervous system
Nervous system
Activation
CNS development
repulsive guidance molecule
Epithelium
Adhesion
Guidance
Signal transduction
signaling pathways
Development
Differentiation
axon guidance
Biological receptor
ISSN:0022-3042, 1471-4159, 1471-4159
Online Access:Get full text
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Summary:It is now well established that the netrin guidance cues and their receptors comprise a major molecular guidance system driving axon pathfinding during nervous system development. One netrin receptor, neogenin, is now emerging as a key regulator of many developmental processes throughout the embryo. Unexpectedly, a new family of neogenin ligands, the repulsive guidance molecule (RGM) family, has recently been identified. The functional outcome of neogenin activation is dictated by both the nature of the ligand as well as the developmental context. Netrin-1-neogenin interactions mediate chemoattractive axon guidance, while RGMa-neogenin interactions repel axons. Neogenin is required for the establishment of the pseudostratified epithelium of the neural tube, probably by promoting cell adhesion. In addition, a role for RGMa and neogenin in neuronal differentiation has been demonstrated. While neogenin signaling cascades are poorly understood, the opposing responses of neogenin to RGMa and netrin-1 in the context of axon guidance indicates that neogenin signaling is complex and subject to tight spatiotemporal regulation. In summary, neogenin is a multifunctional receptor regulating diverse developmental processes. Thus, its contribution to neural development is proving to be considerably more extensive than originally predicted.
Bibliography:http://dx.doi.org/10.1111/j.1471-4159.2008.05485.x
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ISSN:0022-3042
1471-4159
1471-4159
DOI:10.1111/j.1471-4159.2008.05485.x