Screening the pandemic response box identified benzimidazole carbamates, Olorofim and ravuconazole as promising drug candidates for the treatment of eumycetoma

Eumycetoma is a chronic subcutaneous neglected tropical disease that can be caused by more than 40 different fungal causative agents. The most common causative agents produce black grains and belong to the fungal orders Sordariales and Pleosporales. The current antifungal agents used to treat eumyce...

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Bibliographic Details
Published in:	PLoS neglected tropical diseases Vol. 16; no. 2; p. e0010159
Main Authors:	Lim, Wilson, Nyuykonge, Bertrand, Eadie, Kimberly, Konings, Mickey, Smeets, Juli, Fahal, Ahmed, Bonifaz, Alexandro, Todd, Matthew, Perry, Benjamin, Samby, Kirandeep, Burrows, Jeremy, Verbon, Annelies, van de Sande, Wendy
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.02.2022 Public Library of Science (PLoS)
Subjects:	Acetamides - pharmacology Agents Amputation Animals Antifungal agents Antifungal Agents - pharmacology Ascomycota - drug effects Benzimidazoles Biology and Life Sciences Carbamates (tradename) Carbendazim Causes of Diagnosis Drug development Drug Discovery Drug Evaluation, Preclinical Drug therapy Drugs Fenbendazole - pharmacology Fungal diseases Fungal infections Fungi Fungicides Growth Identification and classification Itraconazole Larvae Madurella - drug effects Malaria Medicine and Health Sciences Metabolism Molecules Moths - microbiology Mycetoma - drug therapy Mycoses Neglected Diseases Optimization Pandemics Pathogens Phylogenetics Physical Sciences Piperazines - pharmacology Pyrimidines - pharmacology Pyrroles - pharmacology R&D Ravuconazole Research & development Surgery Survival Tafenoquine Terbinafine Testing Thiazoles - pharmacology Triazoles - pharmacology Tropical climate Tropical diseases Netherlands Mexico
ISSN:	1935-2735, 1935-2727, 1935-2735
Online Access:	Get full text
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